Naslov
Transcriptional and posttranscriptional mechanisms of neuronal migration

Autori
Krsnik, Željka ; Popovitchenko, Tatiana ; Rasin, Mladen-Roko

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Cellular migration and formation of axons and dendrites, 2nd ed.

Urednik/ci
Rubenstein, John ; Rakic, Pasko ; Chen, Bin ; Kwan, Kenneth Y. ; Kolodkin, Alex ; Anton, Eva

Izdavač
Academic press, an imprint of Elsevier

Grad
London : San Diego (CA)

Godina
2020

Raspon stranica
479-513

ISBN
978-0-12-814407-7

Ključne riječi
radial migration ; tangential migration ; transcription factors ; posttranscriptional mechanisms

Sažetak
Neocortical neurons will assemble into exquisite circuits that will ultimately drive multiple advanced functions such as higher cognition, voluntary motor behavior, and conscious sensory perception. To achieve this, a fundamental set of intricate events has to occur that will bring glutamatergic excitatory projection neurons (also called pyramidal neurons) and GABAergic inhibitory (also called interneurons) from their birth sites using two coexistent but distinct modes of migration. Neocortical glutamatergic neurons use radial migration, whereas GABAergic neurons use tangential migration. Each of the two migration mechanisms has multiple cellular steps that are regulated by intricate molecular events. This chapter summarizes current state of knowledge in transcriptional and posttranscriptional mechanisms involved in the control of radial and tangential migration of neocortical neurons.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA