Pregled bibliografske jedinice broj: 1065262
Cyclodextrin-based drug-delivery systems
Cyclodextrin-based drug-delivery systems // Nanomaterials for clinical applications / Demetzos, Costas ; Pippa, Natassa (ur.).
Amsterdam: Elsevier, 2020. str. 29-69 doi:10.1016/B978-0-12-816705-2.00002-3
CROSBI ID: 1065262 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Cyclodextrin-based drug-delivery systems
Autori
Jug, Mario
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Nanomaterials for clinical applications
Urednik/ci
Demetzos, Costas ; Pippa, Natassa
Izdavač
Elsevier
Grad
Amsterdam
Godina
2020
Raspon stranica
29-69
ISBN
9780128167052
Ključne riječi
cyclodextrin inclusion complex ; solubility ; chemical stability ; parenteral drug delivery ; ocular drug delivery ; nasal drug delivery ; oral drug delivery ; oromucosal drug delivery ; (trans)dermal drug delivery
Sažetak
Natural cyclodextrins (CDs) and their chemically modified derivatives are used nowadays as enabling pharmaceutical excipient capable to increase aqueous solubility of lipophilic drugs, enhance drug chemical stability, reduce volatility, mask unpleasant taste, reduce side effects, and enhance bioavailability, thereby further enabling therapeutic potential and the efficiency of drugs. This chapter provides a brief overview of the CDs chemistry, safety profile, and regulatory status. The mechanism of inclusion complex formation and its fate upon administration to the body is concisely described. The examples of CD-based products in clinical practice and development aimed for parenteral, ocular, nasal, oral, oromucosal, and (trans)dermal administration are presented, critically discussing the benefits and limitations related to CD application in the dosage form development. Finally the use of CDs as novel therapeutically active agents is presented.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
