Naslov
Front cover

Autori
Dean Marković, Maria Kolympadi, Brigitte Deguin, François-Hugues Porée and Māris Turks

Izvornik
Natural product reports (0265-0568) 32 (2015), 2; 106-106

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni

Ključne riječi
neodolastanes, total synthesis, biological activities,

Sažetak
The neodolastane diterpenoids comprise a group of 44 compounds including guanacastepenes, heptemerones, plicatilisins, radianspenes, 2, 15-epoxy-5, 13-dihydroxyneodolast-3-en-14-one and sphaerostanol. These fungal and marine natural products are characterized by tricyclic neodolastane skeleton which consists of fused five-, seven- and six-membered rings. The reported antibiotic activity against antibiotic-resistant bacteria together with strong antifungal andanticancer activities and their novel structures render these compounds as interesting synthetic targets. The aim of this account is to summarise the progress in the isolation, characterisation and synthesis of these diterpenoids as well as to review their biogenetic origin and diverse biological activities since their discovery in 2000.

Izvorni jezik
Engleski

POVEZANOST RADA