Higher Post-Operative Serum Vitamin D Level is Associated with Better Survival Outcome in Colorectal Cancer Patients

Markotic, Antonio; Langer, Sanja; Kelava, Tomislav; Vucic, Katarina; Turcic, Petra; Tokic, Tomislav; Stefancic, Ljilja; Radetic, Eva; Farrington, Susan; Timofeeva, Maria; Rudan, Igor; Campbell, Harry; Dunlop, Malcolm; Kirac, Iva; Zgaga, Lina

doi:10.1080/01635581.2019.1597135

Pregled bibliografske jedinice broj: 1061731

Higher Post-Operative Serum Vitamin D Level is Associated with Better Survival Outcome in Colorectal Cancer Patients

Markotic, Antonio; Langer, Sanja; Kelava, Tomislav; Vucic, Katarina; Turcic, Petra; Tokic, Tomislav; Stefancic, Ljilja; Radetic, Eva; Farrington, Susan; Timofeeva, Maria et al.

Higher Post-Operative Serum Vitamin D Level is Associated with Better Survival Outcome in Colorectal Cancer Patients // Nutrition and cancer, 71 (2019), 7; 1078-1085 doi:10.1080/01635581.2019.1597135 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1061731 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Higher Post-Operative Serum Vitamin D Level is Associated with Better Survival Outcome in Colorectal Cancer Patients

Autori
Markotic, Antonio ; Langer, Sanja ; Kelava, Tomislav ; Vucic, Katarina ; Turcic, Petra ; Tokic, Tomislav ; Stefancic, Ljilja ; Radetic, Eva ; Farrington, Susan ; Timofeeva, Maria ; Rudan, Igor ; Campbell, Harry ; Dunlop, Malcolm ; Kirac, Iva ; Zgaga, Lina

Izvornik
Nutrition and cancer (0163-5581) 71 (2019), 7; 1078-1085

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Colorectal cancer ; 25-hydroxyvitamin D ; survival

Sažetak
25-Hydroxyvitamin D (25-OHD) may have a prognostic value in colorectal cancer (CRC) patients. However, as 25-OHD concentration is strongly impacted by surgery, it is uncertain what is the most reliable time-point for 25-OHD assessment, pre- or post-operative. Therefore, we examined 515 CRC patients (AJCC I-III) who underwent surgery. Blood samples were collected either pre- operatively (n = 286 ; median = 1 day before surgery) or post-operatively (n = 229 ; median = 8 days). Serum 25-OHD concentration was determined by liquid chromatography-tandem mass spectrometry. Association between 25-OHD and survival was tested in the whole cohort, followed by stratified analyses in pre- and post-operatively sampled. Median 25-OHD in the cohort was 36.7 nmol/L and median follow-up time was 5.9 years. There were no differences between pre- and post-operative cohort in age, sex, 25- OHD, AJCC stage, or localization of tumor. After adjustment, higher 25-OHD (>50 nmol/L) was associated with better overall survival only in post-operative (HR = 0.53 ; 95% CI: 0.33-0.84 ; P = 0.006), but not in pre- operative cohort (HR = 1.13 ; 95% CI: 0.77-1.65 ; P = 0.53). In conclusion, higher post-operative 25-OHD levels were associated with better survival outcome in CRC patients, while no such association was found for pre-operative levels. Time-point of blood collection should be addressed carefully in future research as it might affect the prognostic value of 25-OHD in CRC.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za tumore,
Medicinski fakultet, Zagreb

Profili:

Tomislav Kelava (autor)