Naslov
INTRATHECAL DEXAMETHASONE FOR PREVENTION OF COGNITIVE DYSFUNCTION OF SURGICALLY TREATED HIP FRACTURES

Autori
Šakić, Livija ; Šakić, Kata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Regional anaesthesia and pain medicine 43(7)(S1) Abstracts and Highlight Papers of the 37rd Annual European Society of Regional Anaesthesia & Pain Therapy (ESRA) Congress 2018 / - , 2018, E104-e104

Skup
Annual European Society of Regional Anaesthesia & Pain Therapy Congress (ESRA)

Mjesto i datum
Dublin, Irska, 04.09.2018. - 07.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
inrathecal dexamethasone ; spinal anaesthesia ; emergency ; cognitive dysfunction ; hip fracture

Sažetak
Background and Aims: Cognitive dysfunction is a common complication after surgically treated hip fracture in spinal anesthesia. We hypothesized that intrathecal applied dexamethasone could effectively attenuate post-spinal pain and cognitive dysfunction following surgically treated hip fracture. Methods: Sixty male and female patients, ASA II-III, 50-95 years old were included in this prospective and randomized double-blind study. Patients were divided into two equal groups ; group DLSA received 8 mg dexamethasone, group LSA did not receive dexamethasone, each in addition to intrathecal isobaric levobupivacaine 0.5%. Cognitive dysfunction incidence, intensity and recurrence and adverse events were recorded for 10 days after the start of spinal anesthesia. Results: Regression model was statistically significant and it explains 27% variance of dependent variable and it classifies correctly 79% of patients. The exception is the PPBK group without dexamethasone, LSA group, which in comparison to DLSA group, increases probability of cognitive dysfunction occurrence for 7, 67 times (95% CI: 1, 39- 42, 36 ; P=0, 019). Sixty male and female patients, ASA II-III, 50-95 years old were included in this prospective and ran- domized double- blind study. Patients were divided into two equal groups ; group DLSA received 8 mg dexamethasone, group LSA did not receive dexametha- sone, each in addition to intrathecal isobaric levobupivacaine 0.5%. Cognitive dysfunction incidence, intensity and recurrence and adverse events were recorded for 10 days after the start of spinal anesthesia. Conclusions: Intrathecal applied dexamethasone was effective in attenuation of cognitive dysfunction compared to placebo in patients scheduled for surgically treated hip fracture under spinal anesthesia with less adverse events.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA