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Pregled bibliografske jedinice broj: 1060506

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

Halder, Swagata; Torrecilla, Ignacio; Burkhalter, Martin D.; Popović, Marta; Fielden, John; Vaz, Bruno; Oehler, Judith; Pilger, Domenic; Lessel, Davor; Wiseman, Katherine et al.
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication // Nature communications, 10 (2019), 1; 1-18 doi:10.1038/s41467-019-11095-y (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1060506 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

Autori
Halder, Swagata ; Torrecilla, Ignacio ; Burkhalter, Martin D. ; Popović, Marta ; Fielden, John ; Vaz, Bruno ; Oehler, Judith ; Pilger, Domenic ; Lessel, Davor ; Wiseman, Katherine ; Singh, Abhay Narayan ; Vendrell, Iolanda ; Fischer, Roman ; Philipp, Melanie ; Ramadan, Kristijan

Izvornik
Nature communications (2041-1723) 10 (2019), 1; 1-18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
SPRTN ; Chk1 ; DNA replication ; DNA-protein crosslinks

Sažetak
The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA replication in vertebrate cells. Cells deficient in SPRTN protease exhibit DPC-induced replication stress and genome instability, manifesting as premature ageing and liver cancer. Here, we provide a body of evidence suggesting that SPRTN activates the ATR-CHK1 phosphorylation signalling cascade during physiological DNA replication by proteolysis-dependent eviction of CHK1 from replicative chromatin. During this process, SPRTN proteolyses the Cterminal/inhibitory part of CHK1, liberating N-terminal CHK1 kinase active fragments. Simultaneously, CHK1 full length and its N-terminal fragments phosphorylate SPRTN at the C-terminal regulatory domain, which stimulates SPRTN recruitment to chromatin to promote unperturbed DNA replication fork progression and DPC repair. Our data suggest that a SPRTN-CHK1 cross-activation loop plays a part in DNA replication and protection from DNA replication stress. Finally, our results with purified components of this pathway further support the proposed model of a SPRTN-CHK1 cross-activation loop.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti



POVEZANOST RADA

Projekti:
HRZZ-UIP-2017-05-5258 - Razumijevanje popravka unakrsnog vezanja DNA-Protein in vivo koristeći zebricu kao istraživački model (DNAPRO) (Popović, Marta, HRZZ - 2017-05) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Kristijan Ramadan (autor)

Avatar Url Marta Popović (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Halder, Swagata; Torrecilla, Ignacio; Burkhalter, Martin D.; Popović, Marta; Fielden, John; Vaz, Bruno; Oehler, Judith; Pilger, Domenic; Lessel, Davor; Wiseman, Katherine et al.
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication // Nature communications, 10 (2019), 1; 1-18 doi:10.1038/s41467-019-11095-y (međunarodna recenzija, članak, znanstveni)
Halder, S., Torrecilla, I., Burkhalter, M., Popović, M., Fielden, J., Vaz, B., Oehler, J., Pilger, D., Lessel, D. & Wiseman, K. (2019) SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication. Nature communications, 10 (1), 1-18 doi:10.1038/s41467-019-11095-y.
@article{article, author = {Halder, Swagata and Torrecilla, Ignacio and Burkhalter, Martin D. and Popovi\'{c}, Marta and Fielden, John and Vaz, Bruno and Oehler, Judith and Pilger, Domenic and Lessel, Davor and Wiseman, Katherine and Singh, Abhay Narayan and Vendrell, Iolanda and Fischer, Roman and Philipp, Melanie and Ramadan, Kristijan}, year = {2019}, pages = {1-18}, DOI = {10.1038/s41467-019-11095-y}, keywords = {SPRTN, Chk1, DNA replication, DNA-protein crosslinks}, journal = {Nature communications}, doi = {10.1038/s41467-019-11095-y}, volume = {10}, number = {1}, issn = {2041-1723}, title = {SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication}, keyword = {SPRTN, Chk1, DNA replication, DNA-protein crosslinks} }
@article{article, author = {Halder, Swagata and Torrecilla, Ignacio and Burkhalter, Martin D. and Popovi\'{c}, Marta and Fielden, John and Vaz, Bruno and Oehler, Judith and Pilger, Domenic and Lessel, Davor and Wiseman, Katherine and Singh, Abhay Narayan and Vendrell, Iolanda and Fischer, Roman and Philipp, Melanie and Ramadan, Kristijan}, year = {2019}, pages = {1-18}, DOI = {10.1038/s41467-019-11095-y}, keywords = {SPRTN, Chk1, DNA replication, DNA-protein crosslinks}, journal = {Nature communications}, doi = {10.1038/s41467-019-11095-y}, volume = {10}, number = {1}, issn = {2041-1723}, title = {SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication}, keyword = {SPRTN, Chk1, DNA replication, DNA-protein crosslinks} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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