Naslov
Flavonoid release using combined permanent and alternating magnetic fields

Autori
Mandić, Lucija ; Sadžak, Anja ; Mustapić, Mislav ; Baranović, Goran ; Šegota, Suzana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
ESC2019 Book of Abstracts / - , 2019, 8-8

Skup
European Student Colloid Conference

Mjesto i datum
Varna, Bugarska, 18.06.2019. - 22.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mesoporous nanoparticles ; drug release ; loading efficiency ; flavonoids

Sažetak
Due to their specific porous structure and superparamagnetic property, mesoporous clusters could allow physical delivering of active biomolecules to the target area through the influences of an external magnetic fields [1]. Thus, the total concentration of active drug administered into an organism is reduced drastically and side effects are avoided. Intention was to use the flavonoid loaded clusters of magnetite nanoparticles as vectors that can be directed by means of magnetic field gradient towards a certain location. Loading of poorly soluble, hydrophobic flavonoid onto mesoporous clusters comprised of coated PEG magnetite nanoparticles and their release under the influence of permanent and/or alternating magnetic field was investigated [2]. Besides low toxicity, the investigated mesoporous clusters are shown to possess an advantageous feature of higher loading efficiency of flavonoids [3]. In addition to electrostatic interaction between hydroxyl groups at the surface of the Fe3O4 clusters, governing the initial stages of drug loading, the interactions between flavonoid molecules contribute to high loading efficiency. The stabilization is considered crucial especially in biological applications. However, if the idea is to bring unusually high quantity of flavonoid into the intestinal tract the use of flavonoid loaded clusters seems reasonable. This study confirmed that the mesoporous Fe3O4 nanoparticle clusters presents an universal, stable and excellent drug delivery material particularly able to load and release with higher efficiency flavonoids of different physico-chemical and/or structural properties. The fine-tuning of flavonoid release by means of weak external magnetic field oscillating with very low frequency was demonstrated indicating the high potential of mesoporous material as drug carriers.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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