Pregled bibliografske jedinice broj: 1059886
Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer's Disease.
Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer's Disease. // Current alzheimer research, 7 (2020), 141-157 doi:10.2174/1567205017666200317092310 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1059886 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Dehydroepiandrosterone (DHEA) and its Sulphate
(DHEAS) in Alzheimer's Disease.
Autori
Švob Štrac, Dubravka ; Konjevod, Marcela, Nikolac Perković, Matea ; Tudor, Lucija ; Nedić Erjavec Gordana ; Pivac, Nela
Izvornik
Current alzheimer research (1567-2050) 7
(2020);
141-157
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Alzheimer's disease ; Dehydroepiandrosterone ; In vitro studies ; animal models ; dehydroepiandrosterone sulphate ; patients ; treatment
Sažetak
BACKGROUND:Neurosteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are involved in many important brain functions, including neuronal plasticity and survival, cognition and behavior, demonstrating preventive and therapeutic potential in different neuro-psychiatric and neurodegenerative disorders, including Alzheimer's disease. OBJECTIVE: The aim of the article was to provide a comprehensive overview of the literature on the involvement of DHEA and DHEAS in Alzheimer's disease. METHOD: PubMed and MEDLINE databases were searched for relevant literature. The articles were selected considering their titles and abstracts. In the selected full texts, lists of references were searched manually for additional articles. RESULTS: We performed a systematic review of the studies investigating the role of DHEA and DHEAS in various in vitro and animal models, as well as in patients with Alzheimer's disease, and provided a comprehensive discussion on their potential preventive and therapeutic applications. CONCLUSION: Despite mixed results, the findings of various preclinical studies are generally supportive of the involvement of DHEA and DHEAS in the pathophysiology of Alzheimer's disease, showing some promise for potential benefits of these neurosteroids in the prevention and treatment. However, so far small clinical trials brought little evidence to support their therapy in AD. Therefore, large-scale human studies are needed to elucidate the specific effects of DHEA and DHEAS and their mechanisms of action, prior to their applications in clinical practice.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2019-04-6100 - Terapijski potencijal neurosteroida i neurotrofina u demenciji (TePoNeDe) (Švob Štrac, Dubravka, HRZZ - 2019-04) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Marcela Konjevod
(autor)
Gordana Nedić Erjavec
(autor)
Dubravka Švob Štrac
(autor)
Lucija Tudor
(autor)
Nela Pivac
(autor)
Matea Nikolac Perković
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE