Naslov
Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma

Autori
Cumbo, Marija ; Tomić, Branko ; Dunjić, Sofija ; Jovanović, Tamara ; Gvozdenov, Maja ; Pruner, Iva ; Aralica, Gorana ; Kapitanović, Sanja ; Čačev, Tamara ; Đorđević, Valentina

Izvornik
Anticancer research (0250-7005) 39 (2019), 11; 6067-6071

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
colon adenocarcinoma ; normal adjacent tissue ; prothrombin ; tumor ; 3'end gene variants

Sažetak
Background/ Aim: Thrombin plays significant roles in various types of cancer. However, the expression levels of prothrombin, the thrombin precursor, in cancer remain unclear. Variants of the 3'end of the prothrombin gene lead to increased prothrombin expression. This study aimed to analyze prothrombin 3'end gene variants in colon tumor and adjacent normal tissue samples. Materials and Methods: The study group consisted of 93 patients suffering from colon adenocarcinoma. The 3'end of the prothrombin gene was analyzed by DNA sequencing. Results: Three variants, all previously associated with increased prothrombin expression were detected. Frequency of the FII 19911G allele was 46.77% and 47.85% in tumor and normal tissue, respectively. For the FII 20210A allele, the detected frequencies were 2.15% and 1.61%, respectively. The frequency of the FII c.1824T allele was 0.54% in both tissues. Four patients showed different genotypes in tumor and normal tissue. Conclusion: Prothrombin 3' end gene variants may play a role in colorectal cancer.

Izvorni jezik
Hrvatski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Rad je rezultat suradnje na bilateralnom projektu Uloga protrombina u karcinomu debelog crijeva.

POVEZANOST RADA