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Pregled bibliografske jedinice broj: 1058911

Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants

Kovarik, Zrinka; Maček Hrvat, Nikolina
Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants // Neuropharmacology, 171 (2020), 1-7 doi:10.1016/j.neuropharm.2020.108111 (međunarodna recenzija, pregledni rad, znanstveni)

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Naslov
Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants

Autori
Kovarik, Zrinka ; Maček Hrvat, Nikolina

Izvornik
Neuropharmacology (0028-3908) 171 (2020); 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
antidotes ; cholinesterase ; organophosphates ; oximes ; phosphorylation ; 2-PAM

Sažetak
The recent advancements in crystallography and kinetics studies involving reactivation mechanism of acetylcholinesterase (AChE) inhibited by nerve agents have enabled a new paradigm in the search for potent medical countermeasures in case of nerve agents exposure. Poisonings by organophosphorus compounds (OP) that lead to life-threatening toxic manifestations require immediate treatment that combines administration of anticholinergic drugs and an aldoxime as a reactivator of AChE. An alternative approach to reduce the in vivo toxicity of OP centers on the use of bioscavengers against the parent organophosphate. Our recent research showed that site-directed mutagenesis of AChE can enable aldoximes to substantially accelerate the reactivation of OP-enzyme conjugates while dramatically slowing down rates of OP-conjugate dealkylation (aging). Therefore, this review focuses on oxime-assisted catalysis by AChE mutants that provides a potential means for degradation of organophosphates in the plasma before reaching the cellular target site.

Izvorni jezik
Engleski



POVEZANOST RADA

Projekti:
HRZZ-IP-2013-11-4307 - Dizajn, sinteza i evaluacija novih protuotrova kod trovanja živčanim bojnim otrovima i pesticidima (CHOLINESTERASE) (Kovarik, Zrinka, HRZZ - 2013-11) ( CroRIS)
HRZZ-IP-2018-01-7683 - Analiza interakcija butirilkolinesteraze s novim inhibitorima i reaktivatorima (AnalyseBChE) (Kovarik, Zrinka, HRZZ - 2018-01) ( CroRIS)

Profili:

Avatar Url Nikolina Macek Hrvat (autor)

Avatar Url Zrinka Kovarik (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.sciencedirect.com www.sciencedirect.com

Citiraj ovu publikaciju:

Kovarik, Zrinka; Maček Hrvat, Nikolina
Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants // Neuropharmacology, 171 (2020), 1-7 doi:10.1016/j.neuropharm.2020.108111 (međunarodna recenzija, pregledni rad, znanstveni)
Kovarik, Z. & Maček Hrvat, N. (2020) Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants. Neuropharmacology, 171, 1-7 doi:10.1016/j.neuropharm.2020.108111.
@article{article, author = {Kovarik, Zrinka and Ma\v{c}ek Hrvat, Nikolina}, year = {2020}, pages = {1-7}, DOI = {10.1016/j.neuropharm.2020.108111}, keywords = {antidotes, cholinesterase, organophosphates, oximes, phosphorylation, 2-PAM}, journal = {Neuropharmacology}, doi = {10.1016/j.neuropharm.2020.108111}, volume = {171}, issn = {0028-3908}, title = {Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants}, keyword = {antidotes, cholinesterase, organophosphates, oximes, phosphorylation, 2-PAM} }
@article{article, author = {Kovarik, Zrinka and Ma\v{c}ek Hrvat, Nikolina}, year = {2020}, pages = {1-7}, DOI = {10.1016/j.neuropharm.2020.108111}, keywords = {antidotes, cholinesterase, organophosphates, oximes, phosphorylation, 2-PAM}, journal = {Neuropharmacology}, doi = {10.1016/j.neuropharm.2020.108111}, volume = {171}, issn = {0028-3908}, title = {Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants}, keyword = {antidotes, cholinesterase, organophosphates, oximes, phosphorylation, 2-PAM} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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