Naslov
Association of asthma symptoms and exacerbation with inflammatory biomarkers

Autori
Navratil, M ; Ivković-Jureković, I ; Topalušić, I ; Švigir A ; Andrijašević, N ; Rubić, F

Izvornik
Clinical pediatrics: Open access (0009-9228) 2 (2017); 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Asthma ; Biomarkers ; Exhaled breath condensate ; Exhaled breath temperature ; High-sensitive C-reactive protein

Sažetak
Objective: To investigate a relationship of asthma symptoms and exacerbations with systemic (high-sensitivity Creactive protein (hs-CRP), eosinophilic cationic protein (ECP), leukocytes) and local (exhaled NO (FENO), pH and urates in exhaled breath condensate (EBC) and exhaled breath temperature (EBT)) inflammatory biomarkers (BMs) in asthmatic children. Methods: This cross-sectional study comprised 93 consecutive asthmatic patients (age 6-18 years, 22 girls) with mild intermittent asthma ([IA], N=44) and mild to moderate persistent asthma ([PA], N=49). Medical history (asthma symptoms and exacerbation), pulmonary function, FENO, EBT, samples of exhaled breath and peripheral blood were collected. Results: Local BMs (EBC urates and EBT) showed stronger correlation with asthma symptoms then systemic BMs (hs-CRP, blood count with differencials) (r=0.26-0.68, r=0.06-0.32, p<0.05 ; respectively). Single measurements of inflammatory BMs are not good predictors for future asthma exacerbation (binary logistic regression ; χ²=13.9 ; df=11 ; p=0.238). Conclusion: Study of combination of various exhaled breath and exhaled breath condensate BMs should continue, especially in longitudinal studies with repeated measurements of BMs.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA