Naslov
Biomarkers detected by the infrared spectroscopy in spent media metabolomes of embryo- derived teratomas treated with valproate in vivo
(Biomarkers detected by the infrared spectroscopy in spent media metabolomes of embryo-derived teratomas treated with valproate in vivo)

Autori
Plazibat, Milvija ; Katušić-Bojana, Ana ; Himelreich Perić, Marta ; Gamulin, Ozren ; Radonić, Vedran ; Škrabić, Marko: Krajačić, Maria ; Krasić, Jure ; Sinčić, Nino ; Jurić Lekić, Gordana ; Balarin, Maja ; Bulić- Jakuš, Floriana ; Rašić, Mario

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts : HDBMB2019 : crossroads in life sciences / Katalinić, Maja ; Dulić, Morana ; Stuparević, Igor - Zagreb : Hrvatsko Društvo za Biotehnologiju, 2019, 73-73

ISBN
978-953-95551-7-5

Skup
Congress of the Croatian Society of Biochemistry and Molecular Biology "Crossroads in Life Sciences" (HDBMB2019)

Mjesto i datum
Lovran, Hrvatska, 25.09.2019. - 28.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
embryo ; teratomas ; spectrosccopy

Sažetak
Spectroscopy screening of metabolomes detect biological activity of the epigenetic-valproate - derived teratomas in vivo.Principal component analysis of FTIR results showed that spent media metabolomes formed well‐separated clusters reflecting the treatment and day of cultivation. In metabolomes of VPA‐treated teratomas, we found elevation of previously described histone acetylation biomarkers [amide I α‐helix and A(CH3)/A(CH2)]) with apoptotic biomarkers within the amide I region for β‐sheets, and unordered and CH2 vibrations of lipids. VPA may be proposed for therapy of the undifferentiated component of teratoma tumors and this biological system completed by metabolome analysis, for a faster dual screening of antitumor/embryotoxic agents.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA