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Pregled bibliografske jedinice broj: 1057756

Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate

Plazibat, Milvija; Katušić Bojanac, Ana; Himelreich Perić, Marta; Gamulin, Ozren; Rašić, Mario; Radonić, Vedran; Škrabić, Marko; Krajačić, Maria; Krasić, Jure; Sinčić, Nino et al.
Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate // The FEBS journal, 287 (2020), 21; 4783-4800 doi:10.1111/febs.15248 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1057756 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate
(Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate)

Autori
Plazibat, Milvija ; Katušić Bojanac, Ana ; Himelreich Perić, Marta ; Gamulin, Ozren ; Rašić, Mario ; Radonić, Vedran ; Škrabić, Marko ; Krajačić, Maria ; Krasić, Jure ; Sinčić, Nino ; Jurić-Lekić, Gordana ; Balarin, Maja ; Bulić-Jakuš, Floriana

Izvornik
The FEBS journal (1742-464X) 287 (2020), 21; 4783-4800

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
histone deacetylase inhibitor ; IRspectroscopy ; teratoma ; valproate

Sažetak
Lysine acetylation activity of VPA exerts a deleterious effect on the development of the embryo-derived teratoma in vitro that may suggest a novel strategy in the therapy of teratoma tumors in vivo. By analyzing metabolomes from the spent media by FTIR spectroscopy that we associated with the developmental dynamics and bio markers of histone acetylation and apoptosis, we completed the biological system. These findings lead us to the conclusion that the embryo-derived teratoma system, completed by the rapid FTIR spectroscopy, represents arobust, fast dual in vitro screening biological system for the antitumor and embryotoxic/teratogenic agent

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Klinička bolnica "Merkur",
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Opća bolnica Zabok,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Profili:

Avatar Url Maja Balarin (autor)

Avatar Url Marko Škrabić (autor)

Avatar Url Gordana Jurić-Lekić (autor)

Avatar Url Marta Himelreich Perić (autor)

Avatar Url Jure Krasić (autor)

Avatar Url Floriana Jakuš (autor)

Avatar Url Ozren Gamulin (autor)

Avatar Url Maria Krajačić (autor)

Avatar Url Nino Sinčić (autor)

Avatar Url Milvija Plazibat (autor)

Avatar Url Mario Rašić (autor)

Avatar Url Ana Katušić Bojanac (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Plazibat, Milvija; Katušić Bojanac, Ana; Himelreich Perić, Marta; Gamulin, Ozren; Rašić, Mario; Radonić, Vedran; Škrabić, Marko; Krajačić, Maria; Krasić, Jure; Sinčić, Nino et al.
Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate // The FEBS journal, 287 (2020), 21; 4783-4800 doi:10.1111/febs.15248 (međunarodna recenzija, članak, znanstveni)
Plazibat, M., Katušić Bojanac, A., Himelreich Perić, M., Gamulin, O., Rašić, M., Radonić, V., Škrabić, M., Krajačić, M., Krasić, J. & Sinčić, N. (2020) Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate. The FEBS journal, 287 (21), 4783-4800 doi:10.1111/febs.15248.
@article{article, author = {Plazibat, Milvija and Katu\v{s}i\'{c} Bojanac, Ana and Himelreich Peri\'{c}, Marta and Gamulin, Ozren and Ra\v{s}i\'{c}, Mario and Radoni\'{c}, Vedran and \v{S}krabi\'{c}, Marko and Kraja\v{c}i\'{c}, Maria and Krasi\'{c}, Jure and Sin\v{c}i\'{c}, Nino and Juri\'{c}-Leki\'{c}, Gordana and Balarin, Maja and Buli\'{c}-Jaku\v{s}, Floriana}, year = {2020}, pages = {4783-4800}, DOI = {10.1111/febs.15248}, keywords = {histone deacetylase inhibitor, IRspectroscopy, teratoma, valproate}, journal = {The FEBS journal}, doi = {10.1111/febs.15248}, volume = {287}, number = {21}, issn = {1742-464X}, title = {Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate}, keyword = {histone deacetylase inhibitor, IRspectroscopy, teratoma, valproate} }
@article{article, author = {Plazibat, Milvija and Katu\v{s}i\'{c} Bojanac, Ana and Himelreich Peri\'{c}, Marta and Gamulin, Ozren and Ra\v{s}i\'{c}, Mario and Radoni\'{c}, Vedran and \v{S}krabi\'{c}, Marko and Kraja\v{c}i\'{c}, Maria and Krasi\'{c}, Jure and Sin\v{c}i\'{c}, Nino and Juri\'{c}-Leki\'{c}, Gordana and Balarin, Maja and Buli\'{c}-Jaku\v{s}, Floriana}, year = {2020}, pages = {4783-4800}, DOI = {10.1111/febs.15248}, keywords = {histone deacetylase inhibitor, IRspectroscopy, teratoma, valproate}, journal = {The FEBS journal}, doi = {10.1111/febs.15248}, volume = {287}, number = {21}, issn = {1742-464X}, title = {Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate}, keyword = {histone deacetylase inhibitor, IRspectroscopy, teratoma, valproate} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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