Naslov
Epigenetics of Circadian Rhythm Disruption in Cardiovascular Diseases

Autori
Škrlec , Ivana

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Cardiac Diseases

Urednik/ci
Gaze, David C

Izdavač
IntechOpen

Grad
London : Delhi

Godina
2020

Raspon stranica
1-17

ISBN
978-1-83968-162-2

Ključne riječi
DNA methylation ; cardiovascular disease ; circadian rhythm ; epigenetics ; histone modification ; microRNA

Sažetak
Circadian rhythm influences the regulation of homeostasis and physiological processes, and its disruption could lead to metabolic disorders and cardiovascular diseases (CVD). CVDs are still the dominant cause of death worldwide, which are related to numerous environmental and hereditary risk factors. Environmental and hereditary factors can clarify a small fraction of the CVD risk discrepancy. Epigenomics is a very bright strategy that will complement the knowledge of the genetic basis of CVDs. Epigenetic mechanisms allow cells to reply promptly to environmental changes and include DNA methylation, histone modification, and noncoding RNA alterations. According to research data, the circadian rhythm regulates many epigenetic regulators. The challenge is to understand how epigenetic events happen rhythmically in tissues that are involved in the development of CVDs. Epigenetic events are possibly reversible through their interface with environmental and nutritional factors, allowing innovative preventive and therapeutic strategies in cardiovascular diseases.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA