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Pregled bibliografske jedinice broj: 1055050

Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin


Mojzeš, Anamarija; Tomljanović, Marko; Milković, Lidija; Novak Kujundžić, Renata; Čipak Gašparović, Ana; Gall Trošelj, Koraljka
Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin // International journal of molecular sciences, 21 (2020), 5; 1661, 19 doi:10.3390/ijms21051661 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1055050 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin
(Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin)

Autori
Mojzeš, Anamarija ; Tomljanović, Marko ; Milković, Lidija ; Novak Kujundžić, Renata ; Čipak Gašparović, Ana ; Gall Trošelj, Koraljka

Izvornik
International journal of molecular sciences (1422-0067) 21 (2020), 5; 1661, 19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PKM1 ; PKM2 ; SHMT2 ; PHGDH ; STAT3 ; serine ; intracellular localization ; ethanol

Sažetak
In order to support uncontrolled proliferation, cancer cells need to adapt to increased energetic and biosynthetic requirements. One such adjustment is aerobic glycolysis or the Warburg effect. It is characterized by increased glucose uptake and lactate production. Curcumin, a natural compound, has been shown to interact with multiple molecules and signaling pathways in cancer cells, including those relevant for cell metabolism. The effect of curcumin and its solvent, ethanol, was explored on four different cancer cell lines, in which the Warburg effect varied. Vital cellular parameters (proliferation, viability) were measured along with the glucose consumption and lactate production. The transcripts of pyruvate kinase 1 and 2 (PKM1, PKM2), serine hydroxymethyltransferase 2 (SHMT2) and phosphoglycerate dehydrogenase (PHGDH) were quantified with RT-qPCR. The amount and intracellular localization of PKM1, PKM2 and signal transducer and activator of transcription 3 (STAT3) proteins were analyzed by Western blot. The response to ethanol and curcumin seemed to be cell-type specific, with respect to all parameters analyzed. High sensitivity to curcumin was present in the cell lines originating from head and neck squamous cell carcinomas: FaDu, Detroit 562 and, especially, Cal27. Very low sensitivity was observed in the colon adenocarcinoma-originating HT-29 cell line, which retained, after exposure to curcumin, a higher levels of lactate production despite decreased glucose consumption. The effects of ethanol were significant.

Izvorni jezik
Engleski

Znanstvena područja
Glazbena umjetnost



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-4404 - NRF2 na raskrižju epigenetičkog modeliranja, metabolizma i proliferacije stanice raka (CrossEMPATICNRF2) (Gall-Trošelj, Koraljka, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi fulir.irb.hr www.mdpi.com doi.org

Citiraj ovu publikaciju:

Mojzeš, Anamarija; Tomljanović, Marko; Milković, Lidija; Novak Kujundžić, Renata; Čipak Gašparović, Ana; Gall Trošelj, Koraljka
Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin // International journal of molecular sciences, 21 (2020), 5; 1661, 19 doi:10.3390/ijms21051661 (međunarodna recenzija, članak, znanstveni)
Mojzeš, A., Tomljanović, M., Milković, L., Novak Kujundžić, R., Čipak Gašparović, A. & Gall Trošelj, K. (2020) Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin. International journal of molecular sciences, 21 (5), 1661, 19 doi:10.3390/ijms21051661.
@article{article, author = {Mojze\v{s}, Anamarija and Tomljanovi\'{c}, Marko and Milkovi\'{c}, Lidija and Novak Kujund\v{z}i\'{c}, Renata and \v{C}ipak Ga\v{s}parovi\'{c}, Ana and Gall Tro\v{s}elj, Koraljka}, year = {2020}, pages = {19}, DOI = {10.3390/ijms21051661}, chapter = {1661}, keywords = {PKM1, PKM2, SHMT2, PHGDH, STAT3, serine, intracellular localization, ethanol}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms21051661}, volume = {21}, number = {5}, issn = {1422-0067}, title = {Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin}, keyword = {PKM1, PKM2, SHMT2, PHGDH, STAT3, serine, intracellular localization, ethanol}, chapternumber = {1661} }
@article{article, author = {Mojze\v{s}, Anamarija and Tomljanovi\'{c}, Marko and Milkovi\'{c}, Lidija and Novak Kujund\v{z}i\'{c}, Renata and \v{C}ipak Ga\v{s}parovi\'{c}, Ana and Gall Tro\v{s}elj, Koraljka}, year = {2020}, pages = {19}, DOI = {10.3390/ijms21051661}, chapter = {1661}, keywords = {PKM1, PKM2, SHMT2, PHGDH, STAT3, serine, intracellular localization, ethanol}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms21051661}, volume = {21}, number = {5}, issn = {1422-0067}, title = {Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin}, keyword = {PKM1, PKM2, SHMT2, PHGDH, STAT3, serine, intracellular localization, ethanol}, chapternumber = {1661} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • CAB Abstracts
  • EMBASE (Excerpta Medica)


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