Naslov
Bis(triazolylpyrene)-derived Pseudopeptides: Synthesis, Fluorescence Properties and Biological Activity

Autori
Belovari, Mateja ; Nestić, Davor ; Ban, Željka ; Majhen, Dragomira ; Džolić, Zoran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka - XIII. susret mladih kemijskih inženjera / Dejanović, Igor ; Vrsaljko, Domagoj ; Žižek, Krunoslav - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2020, 149-149

ISBN
978-953-6894-71-0

Skup
XIII. susret mladih kemijskih inženjera (SMLKI 2020)

Mjesto i datum
Zagreb, Hrvatska, 20.02.2020. - 21.02.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Pyrene ; Self-assembly ; Nannoaggregates ; Confocal Fluorescence Microscopy

Sažetak
Self-assembled peptide nanostructures are very promising biomaterial with huge potential in several biomedical applications. Pyrene is one of the most useful fluorogenic units due to its high detection sensitivity and its ability to form an excimer. Changes to the intensity of fluorescence emission confirm the formation of self assembled complex. Due to their many interesting fluorescence properties, pyrene and its derivatives are of considerable interest for the development of sensors and diagnostic tools. In aim of design of fluorescent organic nanoparticles, novel products containing pyrene chromophore linked via a triazole ring to an amino acid derivatives were synthesised using Cu-catalized “click” reaction. We report the synthesis of novel bis(triazolylpyrene)-derived pseudopeptides, their photophysical properties, self-assembly in DMSO/H2O as well as confocal fluorescence microscopy studies. Their bioactivity and cellular uptake will be tested on a panel of human tumor cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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