Naslov
Bis(triazolylpyrene)-derived Pseudopeptides: Synthesis, Fluorescence Properties and In Situ Formation of Nanoaggregates in Cells

Autori
Belovari, Mateja ; Ban Željka ; Džolić, Zoran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts / - , 2019, 262-262

Skup
EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC'19)

Mjesto i datum
Atena, Grčka, 01.09.2019. - 05.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
; yrene, Self-assembly ; Fluorescent Organic Nanoparticles ; Nanoaggregates in Cells

Sažetak
Self-assembled peptide nanostructures are very promising biomaterial with huge potential in several biomedical applications. Pyrene is one of the most useful fluorogenic unit because of its high detection sensitivity. Formation of the self assembled complex results in a remarkable change in the fluorescence emission intensities of the pyrene excimer and monomer. Due to their many interesting fluorescence properties, such as long lifetime, high quantum yield, and the possibility to form excimers, pyrene and its derivatives are of considerable interest for the development of sensors and diagnostic tools. In aim of design of fluorescent organic nanoparticles, novel products containing pyrene chromophore linked via a triazole ring to an amino acid derivatives were synthesised using Cu-catalized “click” reaction. We report the synthesis of novel bis(triazolylpyrene)-derived pseudopeptides, their photophysical properties, self-assembly in DMSO/H2O as well as confocal fluorescence microscopy studies. Their bioactivity and cellular uptake will be tested on a panel of human tumor cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA