Pregled bibliografske jedinice broj: 1054420
The shape of titanium dioxide nanomaterials modulates their protection efficacy against ultraviolet light in human skin cells
The shape of titanium dioxide nanomaterials modulates their protection efficacy against ultraviolet light in human skin cells // Journal of nanoparticle research, 22 (2020), 71, 13 doi:10.1007/s11051-020-04791-0 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1054420 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The shape of titanium dioxide nanomaterials modulates their protection efficacy against ultraviolet light in human skin cells
Autori
Ilić, Krunoslav ; Selmani, Atiđa ; Milić, Mirta ; Matijević Glavan, Tanja ; Zapletal, Emilija ; Ćurlin, Marija ; Yokosawa, Tadahiro ; Vinković Vrček, Ivana ; Pavičić, Ivan
Izvornik
Journal of nanoparticle research (1388-0764) 22
(2020);
71, 13
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
UVB radiation ; Skin ; TiO2NM ; Genotoxicity ; Inflammatory response ; Viability ; Health effects
Sažetak
Skin protection against ultraviolet (UV) radiation is necessary to reduce sunburn damage (erythema) and has been recognized as an important preventive measure against the development of cancer. Many sun-blocking pharmaceutical products are based on titanium dioxide nanomaterials (TiO2 NMs) due to their UV barrier properties. This study aimed to assess if the UV protective efficiency of TiO2 NMs depends on their shape. We prepared TiO2 nanowires (TNW), TiO2 nanotubes (TNT), and TiO2 nanoplates (TNP) and tested their effects on human keratinocytes before and after UVB irradiation under in vitro exposure settings. The UVB radiation was applied at the dose equivalent to the UV component observed in one medial erythemal dose. The biological effects of TiO2 NMs on nonirradiated and UVB-irradiated keratinocytes were observed by means of cell viability, genotoxicity, and inflammatory response. The obtained results clearly showed that the effects of TiO2 NMs in vitro, either cytotoxic or protective, depend on their shape. These observations highlight the beneficial properties of nanomaterials that can improve the quality and efficacy of nano-enabled products only if the safe-by-design concept has been implemented during the innovation process.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Farmacija
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-2436 - Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučelje (NanoFaceS) (Vinković Vrček, Ivana, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb
Profili:
Marija Ćurlin
(autor)
Atiđa Selmani
(autor)
Tanja Matijević Glavan
(autor)
Ivana Vinković Vrček
(autor)
Krunoslav Ilić
(autor)
Mirta Milić
(autor)
Emilija Zapletal
(autor)
Ivan Pavičić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus