Naslov
The role of B cells in an early immune response to Mycobacterium bovis

Autori
Krocova, Zuzana ; Plzakova, Lenka ; Pavkova, Ivona ; Kubelkova, Klara ; Macela, Ales ; Ozanic, Mateja ; Marecic, Valentina ; Mihelcic, Mirna ; Santic, Marina

Izvornik
Microbial Pathogenesis (0882-4010) 140 (2020); 103937, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
M. bovis ; BCGB cells ; Receptors ; Cytokines ; Activating marker

Sažetak
Mycobacterium tuberculosis is the main etiological agent of tuberculosis. The Bacillus Calmette-Guérin (BCG) microbes that are primarily used as a vaccine against tuberculosis also constitute the dominant infection model for studying the interaction of mycobacteria with the host cell types. The majority of interaction experiments have been conducted using macrophages and monocytes as prototype phagocyte cell types. Here, we report that M. bovis BCG infects mouse primary B cells as well as human B cell line. The complement receptors, along with B cell receptors, are engaged in the process of bacterial entry into the host B cells. Once inside the B cells, the intracellular trafficking of BCG follows the complete endocytic pathway of the ingested particles, which is in contrast to the events taking place during ingestion of BCG by macrophages. In vivo infection of mice with M. bovis BCG activated peritoneal as well as splenic B cells to produce proinflammatory cytokines. This paper further supports the evidence that B cells are involved in a host's early interactions with intracellular bacterial pathogens and participate in the induction of innate defense responses.

Izvorni jezik
Engleski

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