Association between arsenic exposure and biomarkers of type 2 diabetes mellitus in a Croatian population: A comparative observational pilot study

Lucio, Marianna; Barbir, Rinea; Vučić Lovrenčić, Marijana; Canecki Varžić, Silvija; Ljubić, Spomenka; Smirčić Duvnjak, Lea; Šerić, Vatroslav; Milić, Mirta; Tariba Lovaković, Blanka; Krivohlavek, Adela; Vinković Vrček, Ivana; Michalke, Bernhard

doi:10.1016/j.scitotenv.2020.137575

Pregled bibliografske jedinice broj: 1051825

Association between arsenic exposure and biomarkers of type 2 diabetes mellitus in a Croatian population: A comparative observational pilot study

Lucio, Marianna; Barbir, Rinea; Vučić Lovrenčić, Marijana; Canecki Varžić, Silvija; Ljubić, Spomenka; Smirčić Duvnjak, Lea; Šerić, Vatroslav; Milić, Mirta; Tariba Lovaković, Blanka; Krivohlavek, Adela et al.

Association between arsenic exposure and biomarkers of type 2 diabetes mellitus in a Croatian population: A comparative observational pilot study // Science of the total environment, 720 (2020), 137575, 8 doi:10.1016/j.scitotenv.2020.137575 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1051825 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association between arsenic exposure and biomarkers of type 2 diabetes mellitus in a Croatian population: A comparative observational pilot study

Autori
Lucio, Marianna ; Barbir, Rinea ; Vučić Lovrenčić, Marijana ; Canecki Varžić, Silvija ; Ljubić, Spomenka ; Smirčić Duvnjak, Lea ; Šerić, Vatroslav ; Milić, Mirta ; Tariba Lovaković, Blanka ; Krivohlavek, Adela ; Vinković Vrček, Ivana ; Michalke, Bernhard

Izvornik
Science of the total environment (0048-9697) 720 (2020); 137575, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Arsenic exposure, Type 2 diabetes mellitus, Drinking water, Biomarkers of T2D

Sažetak
Chronic exposure to high inorganic As levels in drinking water has been related to many diseases, including type 2 diabetes mellitus (T2D). The association with low and moderate As levels, however, remains controversial and has yet not been studied in European populations. This study aimed to investigate possible association between As exposure and biomarkers of T2D in Croatian population. Observation recruited 86 adults from Eastern Croatia, where groundwater is contaminated with inorganic As, and 116 adults from Western Croatia, where As levels in drinking water are low. Both populations were divided in patient groups (T2D or prediabetes) and healthy controls. Exposure was assessed by determining total As in blood and urine and As metabolites in urine. Eastern Croatian population had a significantly higher content of As in urine than Western, whereas the opposite was true for arsenobetain. Total As and As metabolites in urine positively correlated with hemoglobin A1c (HbA1c) and negatively with albuminuria. This study provides important preliminary data on the levels of As in urine and blood and their association with biomarkers of T2D in Croatian population exposed to low or moderate levels of As through drinking water as a solid basis for further research of the pathophysiological effects of such As exposure on the status and complications of diabetes.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinička bolnica "Merkur",
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac,
Medicinski fakultet, Zagreb,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek

Profili:

Adela Krivohlavek (autor)