Naslov
Does Cytolysis by CD8+ T Cells Drive Immune Escape in HIV Infection?

Autori
Balamurali, Mehala ; Petravic, Janka ; Loh, Liyen ; Alcantara, Sheilajen ; Kent, Stephen J. ; Davenport, Miles P.

Izvornik
The Journal of Immunology (0022-1767) 185 (2010), 9; 5093-5101

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
immune escape, cytolysis, HIV

Sažetak
CD8+ "cytotoxic" T cells are important for the immune control of HIV and the closely related simian models SIV and chimeric simian-human immunodeficiency virus (SHIV), although the mechanisms of this control are unclear. One effect of CD8+ T cellmediated recognitionofvirus-infected cellsisthe rapid selectionofescape mutant (EM) virus thatisnotrecognized.Toinvestigate the mechanisms of virus-specific CD8 + T cell control during immune escape invivo, we used areal-time PCR assay to study the dynamics of immune escape in early SHIV infection of pigtail macaques. For immune escape mediated by cytolysis, we would expect that the death rate of wild type (WT) infected cells should be faster than that of EM-infected cells. In addition, escape should be fastest during periods when the total viral load is declining. However, we find that there is no significant difference in the rateofdecayof WT virus compared with EM virus. Further, immune escape is often fastest during periods of viral growth, rather than viral decline. These dynamics are consistent with an epitope-specific, MHC class I-restricted, noncytolytic mechanism of CD8+ T cell control of SHIV that specifically inhibits the growth of WT virus in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Matematika, Biologija

POVEZANOST RADA