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Pregled bibliografske jedinice broj: 1050153

The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis

Mattiola, Irene; Tomay, Federica; De Pizzol, Maria; Silva-Gomes, Rita; Savino, Benedetta; Gulic, Tamara; Doni, Andrea; Lonardi, Silvia; Boutet, Marie Astrid; Nerviani, Alessandra et al.
The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis // Nature immunology, 20 (2019), 1012-1022 doi:10.1038/s41590-019-0417-y (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1050153 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis

Autori
Mattiola, Irene ; Tomay, Federica ; De Pizzol, Maria ; Silva-Gomes, Rita ; Savino, Benedetta ; Gulic, Tamara ; Doni, Andrea ; Lonardi, Silvia ; Boutet, Marie Astrid ; Nerviani, Alessandra ; Carriero, Roberta ; Molgora, Martina ; Stravalaci, Matteo ; Morone, Diego ; Shalova, Irina N. ; Lee, Yunquin ; Biswas, Subhra K. ; Mantovani, Giovanna ; Sironi, Marina ; Pitzalis, Costantino ; Vermi, William ; Bottazzi, Barbara ; Mantovani, Alberto ; Locati, Massimo

Izvornik
Nature immunology (1529-2908) 20 (2019); 1012-1022

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
TUMOR-ASSOCIATED MACROPHAGES ; PATTERN-RECOGNITION ; BETA-SUBUNIT ; DECTIN-1 ; RECEPTOR ; CD20 ; IGE ; IMMUNITY ; FAMILY ; POLARIZATION

Sažetak
The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to murine and human mononuclear phagocytes and was induced during monocyte-to-macrophage differentiation in the presence of interleukin 4 or dexamethasone. Human MS4A4A was co-expressed with M2/M2-like molecules in subsets of normal tissue-resident macrophages, infiltrating macrophages from inflamed synovium and tumor-associated macrophages. MS4A4A interacted and colocalized with the β-glucan receptor dectin-1 in lipid rafts. In response to dectin-1 ligands, Ms4a4a-deficient macrophages showed defective signaling and defective production of effector molecules. In experimental models of tumor progression and metastasis, Ms4a4a deficiency in macrophages had no impact on primary tumor growth, but was essential for dectin-1-mediated activation of macrophages and natural killer (NK) cell–mediated metastasis control. Thus, MS4A4A is a tetraspan molecule selectively expressed in macrophages during differentiation and polarization, essential for dectin-1-dependent activation of NK cell–mediated resistance to metastasis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Tamara Gulić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com doi.org

Citiraj ovu publikaciju:

Mattiola, Irene; Tomay, Federica; De Pizzol, Maria; Silva-Gomes, Rita; Savino, Benedetta; Gulic, Tamara; Doni, Andrea; Lonardi, Silvia; Boutet, Marie Astrid; Nerviani, Alessandra et al.
The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis // Nature immunology, 20 (2019), 1012-1022 doi:10.1038/s41590-019-0417-y (međunarodna recenzija, članak, znanstveni)
Mattiola, I., Tomay, F., De Pizzol, M., Silva-Gomes, R., Savino, B., Gulic, T., Doni, A., Lonardi, S., Boutet, M. & Nerviani, A. (2019) The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis. Nature immunology, 20, 1012-1022 doi:10.1038/s41590-019-0417-y.
@article{article, author = {Mattiola, Irene and Tomay, Federica and De Pizzol, Maria and Silva-Gomes, Rita and Savino, Benedetta and Gulic, Tamara and Doni, Andrea and Lonardi, Silvia and Boutet, Marie Astrid and Nerviani, Alessandra and Carriero, Roberta and Molgora, Martina and Stravalaci, Matteo and Morone, Diego and Shalova, Irina N. and Lee, Yunquin and Biswas, Subhra K. and Mantovani, Giovanna and Sironi, Marina and Pitzalis, Costantino and Vermi, William and Bottazzi, Barbara and Mantovani, Alberto and Locati, Massimo}, year = {2019}, pages = {1012-1022}, DOI = {10.1038/s41590-019-0417-y}, keywords = {TUMOR-ASSOCIATED MACROPHAGES, PATTERN-RECOGNITION, BETA-SUBUNIT, DECTIN-1, RECEPTOR, CD20, IGE, IMMUNITY, FAMILY, POLARIZATION}, journal = {Nature immunology}, doi = {10.1038/s41590-019-0417-y}, volume = {20}, issn = {1529-2908}, title = {The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis}, keyword = {TUMOR-ASSOCIATED MACROPHAGES, PATTERN-RECOGNITION, BETA-SUBUNIT, DECTIN-1, RECEPTOR, CD20, IGE, IMMUNITY, FAMILY, POLARIZATION} }
@article{article, author = {Mattiola, Irene and Tomay, Federica and De Pizzol, Maria and Silva-Gomes, Rita and Savino, Benedetta and Gulic, Tamara and Doni, Andrea and Lonardi, Silvia and Boutet, Marie Astrid and Nerviani, Alessandra and Carriero, Roberta and Molgora, Martina and Stravalaci, Matteo and Morone, Diego and Shalova, Irina N. and Lee, Yunquin and Biswas, Subhra K. and Mantovani, Giovanna and Sironi, Marina and Pitzalis, Costantino and Vermi, William and Bottazzi, Barbara and Mantovani, Alberto and Locati, Massimo}, year = {2019}, pages = {1012-1022}, DOI = {10.1038/s41590-019-0417-y}, keywords = {TUMOR-ASSOCIATED MACROPHAGES, PATTERN-RECOGNITION, BETA-SUBUNIT, DECTIN-1, RECEPTOR, CD20, IGE, IMMUNITY, FAMILY, POLARIZATION}, journal = {Nature immunology}, doi = {10.1038/s41590-019-0417-y}, volume = {20}, issn = {1529-2908}, title = {The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis}, keyword = {TUMOR-ASSOCIATED MACROPHAGES, PATTERN-RECOGNITION, BETA-SUBUNIT, DECTIN-1, RECEPTOR, CD20, IGE, IMMUNITY, FAMILY, POLARIZATION} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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