Naslov
Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti- inflammatory drugs and opioids

Autori
Bach-Rojecky, Lidija ; Vađunec, Dalia ; Žunić, Katarina ; Kurija, Jelena ; Šipicki, Sara ; Gregg, Ryan ; Mikula, Ivan ; Primorac, Dragan

Izvornik
Personalized medicine (1741-0541) 16 (2019), 2; 171-184

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
analgesic effect ; epigenetics ; genes ; nonsteroidal anti-inflammatory drugs ; opioids ; pain treatment ; pharmacogenetics ; side effects ; toxicity

Sažetak
Successful pain management requires the delivery of analgesia with minimal risk of adverse drug reactions. Nonsteroidal anti- inflammatory drugs and opioids remain the mainstay of treatment for the majority of patients. Unfortunately, almost 50% of all patients experience inadequate pain relief and serious side effects. Allelic variants in genes coding for target proteins, transporters and enzymes, which govern analgesic drugs action and their fate in the organism, might explain inter-individual variability in pain severity and in drug-induced pain relief and toxicities. Additionally, it seems that epigenetic changes contribute to the highly variable response to pain treatment. Therefore, pharmacogenomic testing might be a valuable tool for personalization of pain treatment, with a multidisciplinary team approach involved

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA