Naslov
Role of lipid phosphatases in cell signalling.

Autori
Mitchell, Christina ; Gurung, Rajendra ; Ivetac, Ivan ; Dyson, Jennifer ; Kong, Anne ; Huysmans, Richard ; Tan, April ; Ooms, Lisa.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FASEB JOURNAL (Vol.18, issue 8, Supplement-S) / - Bethesda (MD) : FEDERATION AMER SOC EXP BIOL., 2004, C314-C314

Skup
Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB)/8th Congress of the International Union for Biochemistry and Molecular Biology

Mjesto i datum
Boston (MA), Sjedinjene Američke Države, 12.06.2004. - 16.06.2004

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
intracellular signalling ; phosphoinositides ; PtdIns 3-kinases ; Akt/PKB ; PtdIns(3, 4, 5)P3 ; PtdIns (3, 4)P2 ; lipid phosphatases ; PTEN ; 5-phosphatases ; 4-phosphatases.

Sažetak
Phosphoinositides are membrane-bound signalling molecules that regulate cell proliferation and survival, cytoskeletal reorganization and vesicular trafficking by mediating recruitment of diverse effector proteins to cellular membranes. Agonist stimulation induces canonical cascades resulting in the transient phosphorylation of PtdIns(4, 5)P2 by PI3K (phosphoinositide 3-kinase) to form PtdIns(3, 4, 5)P3, which is rapidly dephosphorylated by the tumor suppressor 3-phosphatase, PTEN, back to PtdIns(4, 5)P2, or by the 5-ptases (inositol polyphosphate 5-phosphatases), generating PtdIns(3, 4)P2. The 5-ptases also hydrolyse PtdIns(4, 5)P2, forming PtdIns4P. Ten mammalian 5-phosphatases have been identified and these enzymes share the mechanism of catalysis akin to that of apurinic/apyrimidinic endonucleases. In addition, PtdIns(3, 4)P2, generated by the activity of 5-phosphatases on PtdIns(3, 4, 5)P3, is likewise a transient and distinct membrane signal that is further sequentially degraded by Type I and II 4-phosphatases within a sustained signalling paradigm.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA