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Pregled bibliografske jedinice broj: 1049082

Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies


Boban, Marko; Pesa, Vladimir; Persic, Viktor; Zulj, Marinko; Malcic, Ivan; Beck, Natko; Vcev, Aleksandar
Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies // Medical science monitor, 24 (2018), 5084-5092 doi:10.12659/msm.909172 (međunarodna recenzija, članak, znanstveni)


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Naslov
Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies
(Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies)

Autori
Boban, Marko ; Pesa, Vladimir ; Persic, Viktor ; Zulj, Marinko ; Malcic, Ivan ; Beck, Natko ; Vcev, Aleksandar

Izvornik
Medical science monitor (1234-1010) 24 (2018); 5084-5092

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cardiomyopathy, dilated ; gadolinium DTPA ; heart failure ; magnetic resonance imaging ; ventricular remodeling ; cardiomyopathy, hypertrophic ; genes, overlapping

Sažetak
Background: Dilatation and other infrastructural rearrangements of the left ventricle are connected with poor prognosis. The aim of our study was to analyze the overlapping phenotypes and dilatation of the ventricle on impairment of systolic function and existence of late gadolinium enhancement (LGE). Material/Methods: Consecutive sample of cases with dilated left ventricle due to non-ischemic cardiomyopathy and healthy controls were included from our cardiac magnetic resonance imaging (CMR) database for a period of 3 years (n=1551 exams). Results: The study included 127 patients ; 30 (23.6%) with dilated cardiomyopathy (DCM) ; 30 (23.6%) with left ventricular non- compaction (LVNC) ; 13 (10.2%) with hypertrophic cardiomyopathy (HCM), and 50 (39.4%) controls. Overlapping phenotypes were found in 48 (37.8%) of the studied cases. Odds for impairment of systolic function in connection with overlapping phenotypes were estimated at 7.8 (95%-CI: 3.4-17.6), (p<0.001). There were significant differences in geometric parameters for patients with overlapping phenotypes vs. controls, as follows: left ventricle end- diastolic dimension(LVEDD) = 6.6 +/- 0.8 vs. 5.6 +/- 1.0 cm (p<0.001) ; left ventricular ejection fraction (LVEF) = 39.3 +/- 14.0 vs. 52.1 +/- 16.1 (p<0.001) ; and existence of LGE 36 (75.0%) vs. 21 (26.6%), (p<0.001), respectively. Overlapping phenotypes correlated with LVEDD (Spearman's-Rho-CC) = 0.521, p<0.001 ; LVEF (Rho-CC) = -0.447, p<0.001 and LGE (Rho-CC)= 0.472, p<0.001. Conclusions: This study found there are many patients with overlapping phenotypes among NICMPs with dilated left ventricles. Overlapping phenotype was associated with greater LVEDD, lesser systolic function, and commonly existing LGE, which all impose increased cardiovascular risk. Linear midventricular LGE stripe was the most powerfully connected with loss of systolic function.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek,
Thalassoterapia Opatija,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Profili:

Avatar Url Ivan Malčić (autor)

Avatar Url Marinko Žulj (autor)

Avatar Url Aleksandar Včev (autor)

Avatar Url Natko Beck (autor)

Avatar Url Viktor Peršić (autor)

Avatar Url Marko Boban (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Boban, Marko; Pesa, Vladimir; Persic, Viktor; Zulj, Marinko; Malcic, Ivan; Beck, Natko; Vcev, Aleksandar
Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies // Medical science monitor, 24 (2018), 5084-5092 doi:10.12659/msm.909172 (međunarodna recenzija, članak, znanstveni)
Boban, M., Pesa, V., Persic, V., Zulj, M., Malcic, I., Beck, N. & Vcev, A. (2018) Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies. Medical science monitor, 24, 5084-5092 doi:10.12659/msm.909172.
@article{article, author = {Boban, Marko and Pesa, Vladimir and Persic, Viktor and Zulj, Marinko and Malcic, Ivan and Beck, Natko and Vcev, Aleksandar}, year = {2018}, pages = {5084-5092}, DOI = {10.12659/msm.909172}, keywords = {cardiomyopathy, dilated, gadolinium DTPA, heart failure, magnetic resonance imaging, ventricular remodeling, cardiomyopathy, hypertrophic, genes, overlapping}, journal = {Medical science monitor}, doi = {10.12659/msm.909172}, volume = {24}, issn = {1234-1010}, title = {Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies}, keyword = {cardiomyopathy, dilated, gadolinium DTPA, heart failure, magnetic resonance imaging, ventricular remodeling, cardiomyopathy, hypertrophic, genes, overlapping} }
@article{article, author = {Boban, Marko and Pesa, Vladimir and Persic, Viktor and Zulj, Marinko and Malcic, Ivan and Beck, Natko and Vcev, Aleksandar}, year = {2018}, pages = {5084-5092}, DOI = {10.12659/msm.909172}, keywords = {cardiomyopathy, dilated, gadolinium DTPA, heart failure, magnetic resonance imaging, ventricular remodeling, cardiomyopathy, hypertrophic, genes, overlapping}, journal = {Medical science monitor}, doi = {10.12659/msm.909172}, volume = {24}, issn = {1234-1010}, title = {Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies}, keyword = {cardiomyopathy, dilated, gadolinium DTPA, heart failure, magnetic resonance imaging, ventricular remodeling, cardiomyopathy, hypertrophic, genes, overlapping} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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