Naslov
Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases

Autori
Martin, Tiphaine C. ; Šimurina, Mirna ; Ząbczyńska, Marta ; Martinić Kavur, Marina ; Rydlewska, Magdalena ; Pezer, Marija ; Kozłowska, Kamila ; Burri, Andrea ; Vilaj, Marija ; Turek-Jabrocka, Renata ; Krnjajić-Tadijanović, Milena ; Trofimiuk-Müldner, Małgorzata ; Ugrina, Ivo ; Lityńska, Anna ; Hubalewska-Dydejczyk, Alicja ; Trbojević-Akmačić, Irena ; Lin, Ee Mun ; Walsh, John P. ; Pocheć, Ewa ; Spector, Tim D. ; Wilson, Scott G. ; Lauc, Gordan

Izvornik
Molecular & cellular proteomics (1535-9476) 19 (2020), 5; 774-792

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antibodies ; antibody-dependent cell-mediated cytotoxicity (ADCC) ; autoimmune thyroid disease ; fucosylation ; glycoproteins ; glycosylation ; igg ; immunology ; patient cohorts ; thyroid peroxidase antibodies (TPOAB)

Sažetak
Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case- control study with several independent cohorts and over 3, 000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1, 2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody- dependent cell-mediated cytotoxicity previously associated with TPOAb levels.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

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