Naslov
The solvent influence on the complexation of amphiphilic mannosides with β-cyclodextrin and cucurbit[7]uril

Autori
Leko, Katarina ; Petrović-Peroković, Vesna ; Car, Željka ; Pičuljan, Katarina ; Draženović, Josip ; Cindro, Nikola ; Požar, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
47th IUPAC World Chemistry Congress / - , 2019, 2995-2995

Skup
47th IUPAC World Chemistry Congress

Mjesto i datum
Pariz, Francuska, 07.07.2019. - 12.07.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Complexation ; cyclodextrin ; cucurbituril ; hydrophobic effect ; solvation

Sažetak
The solvent influence on the complexation of amphiphilic mannosides containing different non-polar moities with β-cyclodextrin and cucurbit[7]uril was explored in a wide range of temperatures by means of microcalorimetry and NMR spectroscopy. The stabilities of the complexes formed were higher in water than in other hydrogen-bonded solvents (ethylene glycol, formamide, N-methylformamide, and methanol), whereby all reactions were enthalpically controlled. The explored guest preffered cucurbit[7]uril as host. In the case of complexation reactions involving β- cyclodextrin and investigated guests in water notable temperature dependence of ΔrH° and ΔrS° was noticed. This resulted in almost perfect enthalpy-entropy compensation. The standard thermodynamic parameters for mannoside bindng with β-cyclodextrin in organic solvents exhibited relatively weak temperature dependence. The complex stability was strongly influenced by the compatibilty of guest and host cavity sizes, as well as the flexibility and the structure of the mannoside hydrophobic group. The carried out investigations clearly demonstrate that solvophobically driven formation of cyclodextrin and cucurbit[7]uril inclusion complexes is not a water limited phenomenon.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA