Pregled bibliografske jedinice broj: 1047236
Severe lipoatrophy in a patient with type 2 diabetes in response to human insulin analogs glargine and degludec: possible involvement of CD4 T cell–mediated tissue remodeling
Severe lipoatrophy in a patient with type 2 diabetes in response to human insulin analogs glargine and degludec: possible involvement of CD4 T cell–mediated tissue remodeling // Diabetes care, 43 (2019), 2; 494-496 doi:10.2337/dc19-1888 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1047236 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Severe lipoatrophy in a patient with type 2 diabetes in response to human insulin analogs glargine and degludec: possible involvement of CD4 T cell–mediated tissue remodeling
Autori
Turk Wensveen, Tamara ; Fučkar Čupić, Dora ; Jurišić Eržen, Dubravka ; Polić, Bojan ; Wensveen, Felix M.
Izvornik
Diabetes care (0149-5992) 43
(2019), 2;
494-496
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
lipoatrophy ; type 2 diabetes ; human insulin
Sažetak
A female patient age 69 years with .10-year history of type 2 diabetes (T2D), on a therapy of premixed aspart insulin, presented with poor glycemic control (HbA1c 8.7%). Change of therapy to three injections of short- acting aspart and once-daily glargine improved glycemic control but resulted in severe lipoatrophy at all sites of injection, a rare complication of insulin therapy almost exclusively associated with type 1 diabetes (T1D). The patient had C-peptide levels within normal range and lacked autoantibodies against GAD, islet antigen 2 (IA-2), and tissue transglutaminase (tTg), excluding T1D. Glargine injection was replaced by degludec, but this did not prevent formation of new indentures. Histological analysis of tissue biopsies revealed strong tissue remodeling at affected sites including fibrosis, reduction of adipocyte size, and increased vascularization. Immunohistochemical staining showed a strong influx of CD4 T cells in affected sites but no apparent signs of T cell–mediated cell death. Flow cytometry of peripheral blood leukocytes did not show an overt effector cell profile of CD4 T cells, indicating that the response was mediated locally. Our findings indicate that insulin-induced lipoatrophy in the context of T2D is distinct from that seen in T1D and appears to depend on CD4 T cell–mediated tissue remodeling.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
UNIRI 865.10.2101
UNIRI 803.10.1103
HRZZ-IP-2016-06-9306 - Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini (INFLAMETAB) (Polić, Bojan, HRZZ - 2016-06) ( CroRIS)
HRZZ-IP-2016-06-8027 - Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva (T-MEMORY) (Wensveen, Felix Martinus, HRZZ - 2016-06) ( CroRIS)
EK-KK.01.1.1.01.0006 - Jačanje kapaciteta CERVIRVAC-a za istraživanja u virusnoj imunologiji i vakcinologiji (Jonjić, Stipan, EK ) ( CroRIS)
--uniri-biomed-18-117 - Direktni utjecaj hipoglikemija na promjene srčanog ritma u bolesnika sa šećernom bolesti tip 2 (Turk Wensveen, Tamara) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka
Profili:
Dubravka Jurišić-Eržen
(autor)
Tamara Turk Wensveen
(autor)
Dora Fučkar Čupić
(autor)
Bojan Polić
(autor)
Felix Martinus Wensveen
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE