Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1043933

Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent


Habek, Nikola; Dobrivojević Radmilović, Marina; Kordić, Milan; Ilić, Katarina; Grgić, Sandra; Farkaš, Vladimir; Bagarić, Robert; Škokić, Siniša; Švarc, Alfred; Dugandžić, Aleksandra
Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent // Pflügers Archiv, 472 (2020), 405-417 doi:10.1007/s00424-020-02347-8 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1043933 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent

Autori
Habek, Nikola ; Dobrivojević Radmilović, Marina ; Kordić, Milan ; Ilić, Katarina ; Grgić, Sandra ; Farkaš, Vladimir ; Bagarić, Robert ; Škokić, Siniša ; Švarc, Alfred ; Dugandžić, Aleksandra

Izvornik
Pflügers Archiv (0031-6768) 472 (2020); 405-417

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Uroguanylin ; Hypothalamus ; Male vs female ; PET-CT ; MRI ; Infrared thermography

Sažetak
Uroguanylin (UGN) is released from the intestine after a meal. When applied in brain ventricles, UGN increases expression of markers of thermogenesis in brown adipose tissue (BAT). Therefore, we determine the effects of its receptor, guanylate cyclase C (GC-C), on mouse interscapular BAT (iBAT) activity during diet-induced thermogenesis (DIT). The activation of iBAT after a meal is diminished in GC-C KO mice, decreased in female wild type (WT) mice, and abolished in old WT animals. The activation of iBAT after a meal is the highest in male WT animals which leads to an increase in GC-C expression in the hypothalamus, an increase in iBAT volume by aging, and induction of iBAT markers of thermogenesis. In contrast to iBAT activation after a meal, iBAT activation after a cold exposure could still exist in GC-C KO mice and it is significantly higher in female WT mice. The expression of GC-C in the proopiomelanocortin neurons of the arcuate nucleus of the hypothalamus but not in iBAT suggests central regulation of iBAT function. The iBAT activity during DIT has significantly reduced in old mice but an intranasal application of UGN leads to an increase in iBAT activity in a dose- dependent manner which is in strong negative correlation to glucose concentration in blood. This activation was not present in GC-CKOmice. Our results suggest the physiological role of GC-C on the BAT regulation and its importance in the regulation of glucose homeostasis and the development of new therapy for obesity and insulin resistance.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-7416 - Funkcija novo-otkrivenog proteina u mozgu, urogvanilina, od stanične fiziologije do ljudskog zdravlja (FURNACE/FURNACE) (Dugandžić, Aleksandra, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi link.springer.com

Citiraj ovu publikaciju:

Habek, Nikola; Dobrivojević Radmilović, Marina; Kordić, Milan; Ilić, Katarina; Grgić, Sandra; Farkaš, Vladimir; Bagarić, Robert; Škokić, Siniša; Švarc, Alfred; Dugandžić, Aleksandra
Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent // Pflügers Archiv, 472 (2020), 405-417 doi:10.1007/s00424-020-02347-8 (međunarodna recenzija, članak, znanstveni)
Habek, N., Dobrivojević Radmilović, M., Kordić, M., Ilić, K., Grgić, S., Farkaš, V., Bagarić, R., Škokić, S., Švarc, A. & Dugandžić, A. (2020) Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent. Pflügers Archiv, 472, 405-417 doi:10.1007/s00424-020-02347-8.
@article{article, author = {Habek, Nikola and Dobrivojevi\'{c} Radmilovi\'{c}, Marina and Kordi\'{c}, Milan and Ili\'{c}, Katarina and Grgi\'{c}, Sandra and Farka\v{s}, Vladimir and Bagari\'{c}, Robert and \v{S}koki\'{c}, Sini\v{s}a and \v{S}varc, Alfred and Dugand\v{z}i\'{c}, Aleksandra}, year = {2020}, pages = {405-417}, DOI = {10.1007/s00424-020-02347-8}, keywords = {Uroguanylin, Hypothalamus, Male vs female, PET-CT, MRI, Infrared thermography}, journal = {Pfl\"{u}gers Archiv}, doi = {10.1007/s00424-020-02347-8}, volume = {472}, issn = {0031-6768}, title = {Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent}, keyword = {Uroguanylin, Hypothalamus, Male vs female, PET-CT, MRI, Infrared thermography} }
@article{article, author = {Habek, Nikola and Dobrivojevi\'{c} Radmilovi\'{c}, Marina and Kordi\'{c}, Milan and Ili\'{c}, Katarina and Grgi\'{c}, Sandra and Farka\v{s}, Vladimir and Bagari\'{c}, Robert and \v{S}koki\'{c}, Sini\v{s}a and \v{S}varc, Alfred and Dugand\v{z}i\'{c}, Aleksandra}, year = {2020}, pages = {405-417}, DOI = {10.1007/s00424-020-02347-8}, keywords = {Uroguanylin, Hypothalamus, Male vs female, PET-CT, MRI, Infrared thermography}, journal = {Pfl\"{u}gers Archiv}, doi = {10.1007/s00424-020-02347-8}, volume = {472}, issn = {0031-6768}, title = {Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent}, keyword = {Uroguanylin, Hypothalamus, Male vs female, PET-CT, MRI, Infrared thermography} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font