Naslov
NMR study on interaction of silver nanoparticles with biothiols

Autori
Barbir, Rinea ; Pem, Barbara ; Selmani, Atiđa ; Vrček, Valerije ; Vinković Vrček, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 14th Greta Pifat Mrzljak International School of Biophysics, ABC of Physics of Life: Book of abstracts / Delač Marion, Ida ; Vuletić, Tomislav - Split : Institut Ruđer Bošković ; Hrvatsko biofizičko društvo, 2018, 60-60

ISBN
978-953-7941-24-6

Skup
14th Greta Pifat Mrzljak International School of Biophysics: ABC of physics of life

Mjesto i datum
Split, Hrvatska, 23.08.2018. - 01.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NMR ; protein corona ; silver nanoparticles

Sažetak
Introduction of nanoparticles (NPs) to biological environments results in the formation of the so-called biomolecular corona a layer of adsorbed biomolecules on the surface of NPs. The composition and nature of corona and its impact on pharmacodynamics and pharmacokinetics of thusly-modied NPs is a major question in nanomedicine. In this study, we employed nuclear magnetic resonance (NMR) to evaluate interaction of silver NPs with glutathione (GSH), an important biothiol. The selected silver NPs were functionalized with three distinct coatings - non-ionic polyvinylpyrrolidone (PVP), positively charged poly-Llysine (PLL), and negatively charged sodium bis(2- ethylhexyl)sulfosuccinate (AOT). The experiments involved exposing diferent silver NPs to GSH, analysis of size and surface charge by light scattering technique and tracking the change in NMR spectra of GSH.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija

POVEZANOST RADA