Naslov
Impact of continuous P2Y12 inhibition tailoring in acute coronary syndrome and genetically impaired clopidogrel absorption

Autori
Samardžić, Jure ; Božina, Nada ; Skorić, Boško ; Ganoci, Lana ; Krpan, Miroslav ; Petričević, Mate ; Pašalić, Marijan ; Božina, Tamara ; Pavasović, Saša ; Čikes, Maja ; Miličić, Davor

Izvornik
Journal of cardiovascular pharmacology (0160-2446) 75 (2019), 2; 174-179

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dual antiplatelet therapy ; coronary artery disease

Sažetak
Clopidogrel is still widely used in acute coronary syndrome (ACS) despite the development of more potent P2Y12 inhibitors. Previously, we conducted a trial which evaluated serial clopidogrel dose adjustment based on platelet function testing in ACS patients with initial high on-treatment platelet reactivity (HTPR). In this sub-study we performed post hoc analysis of the effect of ABCB1 genetic variants C3435T and G2677T/A on platelet inhibition and outcomes. There were no differences in the proportion of HTPR patients among C3435T carriers and non-carriers in both interventional and control group. G2677T carriers expressed significantly higher proportion of HTPR pattern throughout 12-month follow-up in the control group with no difference in the interventional group. There was no difference in ischemic outcomes between C3435T and G2677T carriers and non-carriers in both groups of patients. The results indicate that ABCB1 genotyping is not useful to guide clopidogrel therapy tailoring to improve high risk patient management.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA