Naslov
Interaction analyses of AChE and BChE with selected pesticides

Autori
Xie, Heidi Qunhui ; Kovarik, Zrinka ; Liu, Yiyun ; Čadež, Tena ; Ma, Yongchao ; Zandona, Antonio ; Luo, Yali ; Šinko, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Abstract book of the 16th International Symposium on Cholinergic Mechanisms, Rehovot, Izrael / - , 2019, 78-78

Skup
16th International Symposium on Cholinergic Mechanisms

Mjesto i datum
Reẖovot, Izrael, 08.12.2019. - 12.12.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Organophosphorous pesticides ; cholinesterase inhibition ; molecular modeling

Sažetak
Intoxication monitoring and intervention solution for pesticides intoxication are essential issues for public health surveillance and control world-wildly. The well-known action mechanism for OP pesticides intoxication is through the inhibition of acetylcholinesterase (AChE), an enzyme critical for cholinergic neurotransmission. Disruption of AChE biosynthesis process by certain pesticides has been evidenced, and was considered as one of the mechanisms for the long-term effects of these compounds. Thus, in order to fully understand the action of these pesticides, their effects and mechanisms on both AChE expression and enzymatic activity merit in- depth investigations. The objectives was to reveal the alterations in the enzymatic activity and expression of AChE caused by selected pesticides (Metamiphos, Phenamidophos, Ethoprophos, Phosalone, and Acetamiprid), to investigate the action mechanisms by in silico methods, and to elucidate cell signaling mechanisms for the AChE dysregulation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA