Pregled bibliografske jedinice broj: 1038337
Expression of apoptotic and proliferation factors in gastric mucosa of patients with systemic sclerosis correlates with form of the disease
Expression of apoptotic and proliferation factors in gastric mucosa of patients with systemic sclerosis correlates with form of the disease // Scientific reports, 9 (2019), 1; 18461, 10 doi:10.1038/s41598-019-54988-0 (međunarodna recenzija, članak, znanstveni)
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Naslov
Expression of apoptotic and proliferation factors
in gastric mucosa of patients with systemic
sclerosis correlates with form of the disease
Autori
Boric, Katarina ; Mardesic, Snjezana ; Martinovic Kaliterna, Dusanka ; Radic, Mislav ; Tadin Hadjina, Ivana ; Vukojevic, Katarina ; Kosovic, Ivona ; Solic, Ivana ; Zekic Tomas, Sandra ; Saraga-Babic, Mirna
Izvornik
Scientific reports (2045-2322) 9
(2019), 1;
18461, 10
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Cell death and immune response, Systemic sclerosis
Sažetak
Despite high prevalence of patients with gastric disease in systemic sclerosis (SSc), its pathogenesis is still poorly understood. We immunohistochemically analysed biopsies of gastric mucosa (GM) in 5 controls and 15 patients with different forms of SSc: limited cutaneous (lc), diffuse cutaneous moderate (sys1) and severe (sys2). The number of positive cells was analysed by a Kruskall-Wallis test, P < 0.05 was considered statistically significant. Percentage of proliferating (Ki-67 positive) cells was highest in sys1 (3% in superficial and 4, 6% in deeper parts of GM), which dropped to 1% in sys2. Percentage of α-smooth muscle actin (α-SMA) positive cells was 5% in controls, 9% in superficial GM, while in deeper GM rose from 7% to 19% in sys1 and sys2, thus indicating increased myofibroblast population. Caspase-3 positive apoptotic cells characterized 1, 5-2% of controls, 8% of superficial and 6% of deeper GM cells in sys1. In sys2, apoptosis affected 50% of surface epithelial and gland cells and 30% of deeper glands, and correlated with increased fibrosis and decreased syndecan-1 expression. Our data demonstrate that sys1 is the most "active" proliferating form of SSc. Sys2 characterize collagen deposition, surface epithelium defects, extensive apoptosis and low proliferation, GM atrophy and loss of function.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Split
Profili:
Ivana Tadin Hađina
(autor)
Sandra Zekić-Tomaš
(autor)
Mislav Radić
(autor)
Ivana Šolić
(autor)
Katarina Vukojević
(autor)
Ivona Kosović
(autor)
Snježana Mardešić
(autor)
Mirna Saraga-Babić
(autor)
Dušanka Martinović Kaliterna
(autor)
Katarina Borić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE