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Pregled bibliografske jedinice broj: 1037614

The Anti‐Campylobacter Activity and Mechanisms of Pinocembrin Action


Klančnik, Anja; Šimunović, Katarina; Kovač, Jasna; Sahin, Orhan; Wu, Zuowei; Vučković, Darinka; Abram, Maja; Zhang, Qijing; Smole Možina, Sonja
The Anti‐Campylobacter Activity and Mechanisms of Pinocembrin Action // Microorganisms, 7 (2019), 675, 15 doi:10.3390/microorganisms7120675 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1037614 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The Anti‐Campylobacter Activity and Mechanisms of Pinocembrin Action

Autori
Klančnik, Anja ; Šimunović, Katarina ; Kovač, Jasna ; Sahin, Orhan ; Wu, Zuowei ; Vučković, Darinka ; Abram, Maja ; Zhang, Qijing ; Smole Možina, Sonja

Izvornik
Microorganisms (2076-2607) 7 (2019); 675, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Campylobacter jejuni ; pinocembrin ; mechanism of antibacterial activity ; gene expression ; virulence

Sažetak
We investigated the anti‐Campylobacter activity of pinocembrin and its mechanism of action, as well as Campylobacter responses to pinocembrin treatment at the genetic and phenotypic levels, using C. jejuni NCTC 11168 and a multidrug efflux system repressor mutant (11168ΔcmeR). At its minimal inhibitory concentration, pinocembrin significantly increased cell membrane permeability of Campylobacter. Interestingly, at sub‐inhibitory concentrations, pinocembrin did not significantly alter membrane functionality and it increased bacterial fitness. Treatment with pinocembrin evoked decreased expression of ribosomal proteins and down‐regulation of several NADH dehydrogenase I chain subunits and proteins involved in iron uptake. This suggests altered protein production and redox cycle and iron metabolism. Interestingly, the chelation of Fe ions during the treatment with pinocembrin increased C. jejuni survival, although there was no increase in the formation of reactive oxygen species. Pre‐treatment of C. jejuni with sub‐inhibitory concentrations of pinocembrin for 2 h resulted in a 1 log decrease in C. jejuni colony forming units in mice liver at 8 days post‐infection, compared to untreated C. jejuni. These findings suggest that pinocembrin modulates the metabolic activity of C. jejuni and that pre‐treatment of C. jejuni with pinocembrin influences its virulence potential in mice. This anti‐ Campylobacter potential of pinocembrin warrants further investigation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka,
Fakultet zdravstvenih studija u Rijeci

Profili:

Avatar Url Maja Abram (autor)

Avatar Url Darinka Vučković (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Klančnik, Anja; Šimunović, Katarina; Kovač, Jasna; Sahin, Orhan; Wu, Zuowei; Vučković, Darinka; Abram, Maja; Zhang, Qijing; Smole Možina, Sonja
The Anti‐Campylobacter Activity and Mechanisms of Pinocembrin Action // Microorganisms, 7 (2019), 675, 15 doi:10.3390/microorganisms7120675 (međunarodna recenzija, članak, znanstveni)
Klančnik, A., Šimunović, K., Kovač, J., Sahin, O., Wu, Z., Vučković, D., Abram, M., Zhang, Q. & Smole Možina, S. (2019) The Anti‐Campylobacter Activity and Mechanisms of Pinocembrin Action. Microorganisms, 7, 675, 15 doi:10.3390/microorganisms7120675.
@article{article, author = {Klan\v{c}nik, Anja and \v{S}imunovi\'{c}, Katarina and Kova\v{c}, Jasna and Sahin, Orhan and Wu, Zuowei and Vu\v{c}kovi\'{c}, Darinka and Abram, Maja and Zhang, Qijing and Smole Mo\v{z}ina, Sonja}, year = {2019}, pages = {15}, DOI = {10.3390/microorganisms7120675}, chapter = {675}, keywords = {Campylobacter jejuni, pinocembrin, mechanism of antibacterial activity, gene expression, virulence}, journal = {Microorganisms}, doi = {10.3390/microorganisms7120675}, volume = {7}, issn = {2076-2607}, title = {The Anti‐Campylobacter Activity and Mechanisms of Pinocembrin Action}, keyword = {Campylobacter jejuni, pinocembrin, mechanism of antibacterial activity, gene expression, virulence}, chapternumber = {675} }
@article{article, author = {Klan\v{c}nik, Anja and \v{S}imunovi\'{c}, Katarina and Kova\v{c}, Jasna and Sahin, Orhan and Wu, Zuowei and Vu\v{c}kovi\'{c}, Darinka and Abram, Maja and Zhang, Qijing and Smole Mo\v{z}ina, Sonja}, year = {2019}, pages = {15}, DOI = {10.3390/microorganisms7120675}, chapter = {675}, keywords = {Campylobacter jejuni, pinocembrin, mechanism of antibacterial activity, gene expression, virulence}, journal = {Microorganisms}, doi = {10.3390/microorganisms7120675}, volume = {7}, issn = {2076-2607}, title = {The Anti‐Campylobacter Activity and Mechanisms of Pinocembrin Action}, keyword = {Campylobacter jejuni, pinocembrin, mechanism of antibacterial activity, gene expression, virulence}, chapternumber = {675} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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