Naslov
Heritability of Human Plasma N-Glycome

Autori
Zaytseva, Olga O. ; Freidin, Maxim B. ; Keser, Toma ; Štambuk, Jerko ; Ugrina, Ivo ; Šimurina, Mirna ; Vilaj, Marija ; Štambuk, Tamara ; Trbojević-Akmačić, Irena ; Pučić-Baković, Maja ; Lauc, Gordan ; Williams, Frances M. K. ; Novokmet, Mislav

Izvornik
Journal of proteome research (1535-3893) 19 (2020), 1; 85-91

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
N-glycosylation ; heritability of glycosylation ; human plasma glycome ; glycan analysis

Sažetak
The N-glycosylation profile of total human plasma proteins could be a useful biomarker for various pathological states. Reliable high- throughput methods for such profiling have been developed. However, studies of relative importance of genetic and environmental factors in regulating plasma N-glycome are scarce. The aim of our study was to determine the role of genetic factors in phenotypic variation of plasma N-glycan profile through the estimates of its heritability. Thirty-nine total plasma N-glycome traits were analyzed in 2816 individuals from the TwinsUK data set. For the majority of the traits, high heritability estimates (>50%) were obtained pointing at a significant contribution of genetic factors in plasma N-glycome variation, especially for glycans mostly attached to immunoglobulins. We have also found several structures with higher environmental contribution to their variation.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Farmacija

POVEZANOST RADA