Naslov
Genome-wide analysis identifies two susceptibility loci for positive thyroid peroxidase and thyroglobulin antibodies

Autori
Matana, Antonela ; Boutin, Thibaud ; Torlak, Vesela ; Brdar, Dubravka ; Gunjača, Ivana ; Kolčić, Ivana ; Boraska Perica, Vesna ; Punda, Ante ; Polašek, Ozren ; Barbalić, Maja ; Hayward, Caroline ; Zemunik, Tatijana

Izvornik
The Journal of clinical endocrinology and metabolism (0021-972X) 105 (2020), 3; 944-951

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genome-wide association study ; meta-analysis ; thyroglobulin antibody ; thyroid peroxidase antibody

Sažetak
INTRODUCTION: Thyroid peroxidase (TPO) and thyroglobulin (Tg) are main components of the thyroid gland and play an essential role in thyroid hormone synthesis. The development of antibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) is the major diagnostic hallmark and early indicator of autoimmune thyroid disease. TPOAb and TgAb are under strong genetic influence ; however, genetic factors that determine thyroid antibody positivity are largely unknown. MATERIALS AND METHODS: To identify novel loci associated with TPOAb and/or TgAb positivity, we performed a genome- wide meta-analysis in a total of 2 613 individuals from Croatia. Participants with elevated plasma TPO-Ab and/or Tg-Ab were defined as cases (N = 619) and those with TPO- Ab and Tg- Ab within reference values were defined as controls (N =1 994). RESULTS: We identified two novel loci, of which one is located within the YES1 gene (rs77284350, P=1.50×10-8), and the other resides within the IRF8 gene (rs16939945, P=5.04×10-8). CONCLUSIONS: Although the observed variants were associated with TPOAb and TgAb positivity for the first time, both YES1 and IRF8 were previously linked to susceptibility to other autoimmune diseases, and represent plausible biological candidates. This study adds to the knowledge of genetics underlying thyroid antibodies and provides a good basis for further research.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti

POVEZANOST RADA