Naslov
Botulinum toxin type A as a prophylactic treatment for tenssion-type headache

Autori
Relja, Maja ; Klepac, Nataša

Izvornik
Neurologia Croatica (0353-8842) 50 (2001);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Sažetak
There have been a number of recent publications on the efficacy of botulinum toxin type (BTX-A) as a prophylactic tratment for chronic tension- type headache (TTH) and migraine. Short-term studies demonstrating the ability of BTX-A to reduce the pain associated with headache have already been reported. The aim of the study was to evaluate the long-term effect of BTX-A as a prophylactic treatment for chronic TTH. Thirty patients with chronic TTH resistant to standard therapy were enrolled in this 28-month prospective study. Firstly, tenderness of pericraniale muscles was evaluated by the manual palpation methods (frontalis, temporalis, trapezius, sternocleidomastoideus/mastoid process) for total tenderness score (TTS). BTX-A as BOTOX (dose range 40-95 U) was injected into the most tender pericranial muscles every 3 months during an 18-month period. Clinical assessment (TTS) and home diary kept by eacha patient were evaluated at 4-week intervals during 18 month. In total, 28 patients (17 female, 11 male) completed this 18-month study. These patients experienced a statistiacally significant decrease in TTS (p<0.001) over the 18-month period. There was a constant and cumulative trend of improvment in the number of headache- free days (p>0.001). No major side effects were reported during the study. Study results support the conclusion that BTX-A may be an effective prophylactic therapy for chronic TTH. However, additional studies are warranted to determine the most successful treatment paradigms.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA