Naslov
Prognostic value of lymphovascular invasion (LVI) in breast cancer patients with clinically node- negative axilla

Autori
Nikles, Iva ; Veliki Dalić, Irena ; Nikles, Sven ; Vuković, Petra ; Raguž, Jelena ; Lonjak, Nikolina ; Šeparović, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Libri oncologici / - , 2017, 36-36

Skup
9th Symposium and Annual Meeting of Croatian Society for Medical Oncology of Croatian Medical Association with International Participation and 11th Meeting of Oncology Pharmacy Section of Croatian Pharmaceutical Society with International Participation

Mjesto i datum
Varaždin, Hrvatska, 20.10.2017. - 22.10.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
hrčak, hrcak, znanstveni časopisi, hrvatski, scientific journals, croatian

Sažetak
Breast cancer in the most common malignancy in women. Incidence rate of breast cancer in Croatia is 119 cases per 100 000 and it is of great importance to identify additional prognostic factors that may have impact on survival. The aim of this study was to determine prognostic value of lymphovascular invasion (LVI) in breast cancer patients with clinically node-negative axilla. Node-negative axilla is determined as absence of metastases in axillary lymph nodes detected by clinical examination or one of the imaging studies (excluding lymphoscintigraphy). Retrospective analysis of medical history was conducted from January 2010 to April 2010 at Universitiy Hospital for Tumors. One hundred and sixty fi ve patients with breast cancer were treated by surgery. Out of total number 114 patients were enrolled and fulfi lled inclusion criteria (primary surgical treatment and clinically node-negative axilla). Statistical analysis was done. Fisher and Chi –square were used to determine corellation between LVI and histological/ clinical factors while Kaplan Meier test was used to determine connection between LVI and overall survival. Survival curves were compared using log- rank test. Value of p<0.05 was statistically signifi cant. Average age of patients at time of diagnosis was 59 years (range 34-85). Average tumor size was 2.2 cm (range 0.5- 9cm). In 72 (63.2%) patients breast conserving surgery was done and 42 (36.8%) patients underwent total mastectomy. All patients underwent axillary staging. Postoperative, ajduvant chemotherapy was admistered in 78 (68.4%) patients. The most common was anthracycline based regimen (74 out of 78 patients). Adjuvant irradiation was delivered in 88 (77.2%) patients, out of which 43 patients underwent only whole breast/chest wall irradiation, and in 45 patients additional regional nodal irradiation was delivered. Five year survival was reached in 92.3% and median follow up was 79 months. Lymphovascular invasion was found in 15 (13.2%) patients. LVI was related with presence of perineural invasion (p<0.001). Statistical analysis showed that LVI was not associated with tumor size, histologic grade, proliferation index Ki67 or with presence of axillary metastases. Moreover, association of LVI with overall survival or recurrence was not found (p=0.499).

Izvorni jezik
Engleski

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