Pregled bibliografske jedinice broj: 1031777
Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial.
Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial. // British journal of dermatology, 181 (2019), 175-185 doi:10.1111/bjd.17633 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1031777 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial.
Autori
Leskur, Dario ; Bukić, Josipa ; Petrić, Ana ; Zekan, Lovre ; Rušić, Doris ; Šešelja Perišin, Ana ; Petrić Ivana ; Stipić, Marija ; Puizina-Ivić, Neira ; Modun, Darko
Izvornik
British journal of dermatology (0007-0963) 181
(2019);
175-185
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
irritant contact dermatitis ; anatomical variation ; sodium lauryl sulphate
Sažetak
BACKGROUND: Sodium lauryl sulfate (SLS)-induced contact dermatitis is a commonly used model for testing the effects of different topical formulations. According to the guidelines, the volar forearms are the preferred testing site ; however, other anatomical locations have been used in previous research, particularly the upper back as the clinically used site for testing different antigens. OBJECTIVES: To investigate the existence of anatomical variations of the skin response to irritation and its effects on the response to treatment. METHODS: Irritation was induced with SLS on symmetrical sites on both forearms and sides of the upper back with additional sites exposed to water as controls. Half of the sites were treated with emollient cream while the other half were left untreated. Irritation was assessed using bioengineering methods and clinical scoring. The trial was registered at ClinicalTrials.gov as NCT03231813. RESULTS: Upper back skin showed higher reactivity to irritants with stronger barrier disruption (measured by Tewameter® , 80·2 ± 18·3 vs. 48·0 ± 24·2 g m-2 h-1 ), more pronounced erythema (measured by Mexameter® , 186·5 ± 88·4 vs. 92·1 ± 58·2 arbitrary units) and dryness (measured by Corneometer® , -28·6 ± 14·5 vs. 2·7 ± 16·9 arbitrary units). Skin recovery rates were also influenced by anatomical location with the upper back showing faster recovery (316·7 ± 223·1 vs. 156·2 ± 198·5). Treatment did not lead to improvement in measured parameters, regardless of anatomical location. CONCLUSIONS: The skin's reaction to irritant and recovery was dependent on anatomical location. The location where testing was conducted should always be reported, as treatments tested across different locations could not be directly compared with each other.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti, Farmacija
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Split
Profili:
Marija Stipić
(autor)
Darko Modun
(autor)
Ana Šešelja Perišin
(autor)
Lovre Zekan
(autor)
Josipa Bukić
(autor)
Doris Rušić
(autor)
Neira Puizina Ivić
(autor)
Dario Leskur
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE