Naslov
Aneurysm morphology and rupture: computational case study using 3D finite elements

Autori
Virag, Lana ; Horvat, Nino ; Karšaj, Igor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Proceeding of the Fourth Soft Tissue Modelling Workshop / - Glasgow : SoftMech Committee (Eds.), 2019, 50-50

Skup
4th Soft Tissue Modelling Workshop

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 05.06.2019. - 07.06.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
abdominal aortic aneurysm ; growth and remodeling ; morphology analysis ; rupture ; finite elements

Sažetak
Abdominal aortic aneurysms (AAAs) are localized dilatations of the infrarenal abdominal aorta. AAAs often remain asymptomatic until rupture, an event with high mortality rate. Current clinical capabilities for predicting rupture remain wanting, and clinical interventions continue to be based primarily on the maximum diameter or expansion rate of the lesion, despite various efforts to find a more reliable rupture criterion, and to increase understanding of the disease. It has been hypothesized that aneurysm morphology are more predictive of rupture risk. Shum et al. (1) defined twenty-five size and shape indices in total, and estimated their importance for aneurysm rupture. In this contribution, using constrained mixture growth and remodelling model of the arterial wall from [2] implemented into 3D finite elements, we computationally study the importance of aneurysm length and axial features on aneurysm expansion rate and likelihood of rupture. During the growth of axially non-symmetric aneurysm increase in arterial curvature (i.e., tortuosity) due to high axial stresses, and local degradation of elastin was observed. Use of different shapes of spatio-temporal elastin degradation function allows us simulation of effects of possible elastase diffusion directions (e.g., in radial-circumferential plane or perpendicular to aneurysm geometry). Moreover, elastin degradation function determines aneurysm sac shape. We compared numerical results with their clinical findings from [2] showing the effects of morphological features (e.g., length, tortuosity, maximum diameter to length radio, asymmetry factor) on likelihood of aneurysm rupture. Our findings agree excellently with the clinics.

Izvorni jezik
Engleski

Znanstvena područja
Strojarstvo

POVEZANOST RADA