Pregled bibliografske jedinice broj: 1030603
An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives
An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives // Croatica chemica acta, 92 (2019), 2; 269-277 doi:10.5562/cca3567 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1030603 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives
Autori
Ismaili, Hamit ; Ban, Željka ; Matić, Josipa ; Saftić, Dijana ; Jukić, Marijana ; Glavaš-Obrovac, Ljubica ; Žinić, Biserka
Izvornik
Croatica chemica acta (0011-1643) 92
(2019), 2;
269-277
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
5-aminouracil ; arylsulfonyl chlorides ; 5-aminosulfonyl uracil derivatives ; in vitro ; anticancer activity
Sažetak
Abstract: Efficient synthesis of 5-aminosulfonyl uracil derivatives 2−9 and results of their antiproliferative activity are provided. Sulfonylation of the amino group in 5-aminouracil 1 with selected arylsulfonyl chlorides occurs regioselectively when the reaction is carried out in pyridine at room temperature. Simple isolation of the products by recrystallization of the crude product mixture from aqueous methanol provides good to excellent yields. The prepared 5-aminosulfonyl uracil derivatives 2−9 were tested for the antiproliferative activity on a panel of seven tumor cell lines of different histological origin (HeLa, Caco-2, NCI-H358, Raji, HuT78, Jurkat, K562) and normal MDCK I cells. Derivatives 2−9 were found more efficient to lymphoma and leukemia cells compared to solid tumor and normal cells.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
VIF2017-MEFOS-8
098-0982914-2935 - Sinteza novih biološki aktivnih derivata nukleobaza i nukleotida (Žinić, Biserka, MZOS ) ( CroRIS)
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA/RNA sekundarne strukture molekularnim kemijskim senzorima (DNA/RNA-MolSense) (Piantanida, Ivo, HRZZ - 2013-11) ( CroRIS)
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Glavaš Obrovac, Ljubica, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Osijek
Profili:
Željka Ban
(autor)
Josipa Matić
(autor)
Dijana Pavlović Saftić
(autor)
Biserka Žinić
(autor)
Marijana Jukić
(autor)
Ljubica Glavaš Obrovac
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus