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Pregled bibliografske jedinice broj: 1030603

An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives


Ismaili, Hamit; Ban, Željka; Matić, Josipa; Saftić, Dijana; Jukić, Marijana; Glavaš-Obrovac, Ljubica; Žinić, Biserka
An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives // Croatica chemica acta, 92 (2019), 2; 269-277 doi:10.5562/cca3567 (međunarodna recenzija, članak, znanstveni)


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Naslov
An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives

Autori
Ismaili, Hamit ; Ban, Željka ; Matić, Josipa ; Saftić, Dijana ; Jukić, Marijana ; Glavaš-Obrovac, Ljubica ; Žinić, Biserka

Izvornik
Croatica chemica acta (0011-1643) 92 (2019), 2; 269-277

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-aminouracil ; arylsulfonyl chlorides ; 5-aminosulfonyl uracil derivatives ; in vitro ; anticancer activity

Sažetak
Abstract: Efficient synthesis of 5-aminosulfonyl uracil derivatives 2−9 and results of their antiproliferative activity are provided. Sulfonylation of the amino group in 5-aminouracil 1 with selected arylsulfonyl chlorides occurs regioselectively when the reaction is carried out in pyridine at room temperature. Simple isolation of the products by recrystallization of the crude product mixture from aqueous methanol provides good to excellent yields. The prepared 5-aminosulfonyl uracil derivatives 2−9 were tested for the antiproliferative activity on a panel of seven tumor cell lines of different histological origin (HeLa, Caco-2, NCI-H358, Raji, HuT78, Jurkat, K562) and normal MDCK I cells. Derivatives 2−9 were found more efficient to lymphoma and leukemia cells compared to solid tumor and normal cells.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
VIF2017-MEFOS-8
098-0982914-2935 - Sinteza novih biološki aktivnih derivata nukleobaza i nukleotida (Žinić, Biserka, MZOS ) ( CroRIS)
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA/RNA sekundarne strukture molekularnim kemijskim senzorima (DNA/RNA-MolSense) (Piantanida, Ivo, HRZZ - 2013-11) ( CroRIS)
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Glavaš Obrovac, Ljubica, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Osijek

Poveznice na cjeloviti tekst rada:

doi doi.org hrcak.srce.hr fulir.irb.hr

Citiraj ovu publikaciju:

Ismaili, Hamit; Ban, Željka; Matić, Josipa; Saftić, Dijana; Jukić, Marijana; Glavaš-Obrovac, Ljubica; Žinić, Biserka
An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives // Croatica chemica acta, 92 (2019), 2; 269-277 doi:10.5562/cca3567 (međunarodna recenzija, članak, znanstveni)
Ismaili, H., Ban, Ž., Matić, J., Saftić, D., Jukić, M., Glavaš-Obrovac, L. & Žinić, B. (2019) An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives. Croatica chemica acta, 92 (2), 269-277 doi:10.5562/cca3567.
@article{article, author = {Ismaili, Hamit and Ban, \v{Z}eljka and Mati\'{c}, Josipa and Safti\'{c}, Dijana and Juki\'{c}, Marijana and Glava\v{s}-Obrovac, Ljubica and \v{Z}ini\'{c}, Biserka}, year = {2019}, pages = {269-277}, DOI = {10.5562/cca3567}, keywords = {5-aminouracil, arylsulfonyl chlorides, 5-aminosulfonyl uracil derivatives, in vitro, anticancer activity}, journal = {Croatica chemica acta}, doi = {10.5562/cca3567}, volume = {92}, number = {2}, issn = {0011-1643}, title = {An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives}, keyword = {5-aminouracil, arylsulfonyl chlorides, 5-aminosulfonyl uracil derivatives, in vitro, anticancer activity} }
@article{article, author = {Ismaili, Hamit and Ban, \v{Z}eljka and Mati\'{c}, Josipa and Safti\'{c}, Dijana and Juki\'{c}, Marijana and Glava\v{s}-Obrovac, Ljubica and \v{Z}ini\'{c}, Biserka}, year = {2019}, pages = {269-277}, DOI = {10.5562/cca3567}, keywords = {5-aminouracil, arylsulfonyl chlorides, 5-aminosulfonyl uracil derivatives, in vitro, anticancer activity}, journal = {Croatica chemica acta}, doi = {10.5562/cca3567}, volume = {92}, number = {2}, issn = {0011-1643}, title = {An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives}, keyword = {5-aminouracil, arylsulfonyl chlorides, 5-aminosulfonyl uracil derivatives, in vitro, anticancer activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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