Naslov
Is oxidative stress a link between harmful effects of high NaCl intake and veneficiary effects of N-3 PUFAs intake on microcirculation in normotensive subjects?

Autori
Drenjančević, Ines ; Stupin, Ana ; Matic, Anita ; Mihaljević, Zrinka ; Mihalj, Martina ; Jukić, Ivana ; Kozina, Nataša ; Rašić, LIdija ; Kolar, Luka ; Kolobarić, Nikolina, Šušnjara, Petar ; Stupin, Marko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European SOciety for Vascular Medicine Contress 2019, International Union of ANgiology- EUrochap 2019, Central European Vascular Forum- Course 2019, Programme with book of abstract / - , 2019, 35-35

Skup
European Society for Vascular Medicine Congress, International Union of Angiology (Eurochap 2019)

Mjesto i datum
Ljubljana, Slovenija, 10.10.2019. - 12.10.2019

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
n-3 PUFAs, enriched eggs, microcirculation, high salt diet
(3 PUFAs, enriched eggs, microcirculation, high salt)

Sažetak
Microcirculation is a highly regulated part of the circulatory system and various dietary factors could affect its function, exerting positive or negative effects. For example, high salt (NaCl) dietary intake is a well known risk factor for the development of hypertension, while microvascular dysfunction develops even without changes in arterial blood pressure. Ultimately, that leads to organ damage and increases the risk of cardiovascular events. Potential mechanisms include decreased NO bioavailability as well as changes in balance of vasoactive eicosanoids, such as metabolites of arachidonic acid, all due to impaired vascular antioxidative mechanisms. On the other hand, new studies demonstrate potentialy protective effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) food intake, as counter-balancing protective arm of vasoactive metabolites potentially alleviating oxidative stress. Animal models and isolated organs studies enable an insight into potential molecular mechanisms and cross talks involved, while in situ human studies provide integrated information on body function and might have clinical implications. Hereby, some recent findings in the vascular tone regulation mechanisms, from assessment of vascular reactivity in response to high salt as a foe, or increased dietary n-3 PUFAs intake (in the form of n-3 PUFAs enriched eggs) as a beneficiary nutrients will be presented. Acknowledgement: This work was supported by European Structural and Investment Funds, grant for the Croatian National Scientific Center of Excellence for Personalized Health Care, University Josip Juraj Strossmayer Osijek, #KK.01.1.1.01.0010. and partially by Croatian Science Foundation grant #IP-2016-06-8744 (RAS-AdrenOX) and Croatian Science Foundation grant #IP-09-2014-6380 (V-ELI Athero).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Pozvani predavač / održala Ines Drenjančević

POVEZANOST RADA