Naslov
Salivary squamous cell carcinoma antigen 1 and 2 in patients with leukoplakia: A pilot study
(Salivary squamous cell carcinoma antigen 1 and 2 in patients with leukoplakia: A pilot study)

Autori
Salarić, Ivan ; Karmelić, Ivana ; Brajdić, Davor ; Zajc, Ivan ; Rožman, Marko ; Baždarić, Ksenija ; Lovrić, Jasna ; Macan, Darko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta stomatologica Croatica, 53 (2019), 3 / - Zagreb, 2019, 292-292

Skup
5. Međunarodni kongres Stomatološkog fakulteta Sveučilišta u Zagrebu = 5th international congress of the School of Dental Medicine University of Zagreb

Mjesto i datum
Zagreb, Hrvatska, 01.03.2019. - 02.03.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
salivary squamous cell carcinoma ; antigen 1 and 2 ; leukoplakia

Sažetak
Aim: Leukoplakia is the most common potentially malignant oral disorder (PMOD) with a worldwide prevalence of 2% and a malignant transformation rate of 0.3%. Squamous cell carcinoma antigens (SCCA) are part of the serpins family. They are involved in inflammation, apoptosis, cell- migration and are expressed in the squamous cell epithelium. SCCA2 protein is 92% homologous to SCCA1, however these antigens are not expressed concurrently and play different roles in the human body. Their role in the healthy and malignant tissues is not clearly understood. Materials and methods: Unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were sampled from 5 patients with leukoplakia (5 male) and 12 age and sex matched control subjects. Leukoplakia was diagnosed with a C2certainty factor. Sandwich human SCCA1 and SCCA2 ELISA Kits, My BioSource, San Diego, USA, were used. Respondents’ alcohol consumption, papilla bleeding index (PBI), smoking, drug consumption and medical condition was registered. This study has been funded by the Croatian Science Foundation (IP-09-2014- 9376). Results: Salivary SCCA1 was significantly higher in patients with leukoplakia in UWS (U=4, p=0.045). No statistically significant difference in SCCA2 levels in UWS and SWS between the two groups was found. Due to the small sample size, smoking, PBI, medical conditions, drug and alcohol consumption had no statistical significance. Conclusion: Salivary SCCA1 could serve as a satisfactory biomarker for leukoplakia. However, a greater sample is needed to establish the diagnostic value of the investigated molecules. To our knowledge, SCCA1 and SCCA2 have not yet been measured in patients with leucoplakia.

Izvorni jezik
Hrvatski, engleski

Znanstvena područja
Fizika, Kemija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Dentalna medicina

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