Naslov
Organometallic derivatives of DNA bases

Autori
Toma, Mateja ; Šakić, Davor ; Lapić, Jasmina ; Djaković, Senka ; Vrček, Valerije

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Humboldt College, SCIENCE AND EDUCATIONAL CHALLENGES FACING EUROPE IN THE NEXT DECADE / Ivanda, Mile ; Skenderović, Hrvoje - Zagreb : Klub hrvatskih humboldtovaca, 2019, 67-68

ISBN
978-953-97333-6-8

Skup
Humboldt College: Science and educational challenges facing Europe in the next decade, On the occasion of the 250th anniversary of the birth of Alexander von Humboldt (1769-1859)

Mjesto i datum
Zagreb, Hrvatska, 10.10.2019. - 11.10.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
organometallics, ferrocene, nucleobases

Sažetak
Organometallic derivatives of nucleobases (OrDeNs) belong to the new generation of conjugates in which metallocenes are linked to the basic structural elements of heredity. Nucleosides in which sugar part is replaced with organometallic moiety, such as ferrocene, combine electro- and bio-active fragments and are of use in (bio)analytical chemistry, and in medicinal chemistry since they are shown to exhibit anticancer and antibacterial activity. An attractive feature of ferrocene is that the vertical distance between the two Cp rings in ferrocene is 0.35 nm, which is similar to the distance between the stacked base pairs in DNA. These could provide useful building blocks in supramolecular chemistry coupling molecular recognition derived from DNA bases with electrochemistry from the redox active ferrocene, leading to the novel applications for the electrochemical recognition of a DNA/RNA binding substrates.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA