Naslov
The expression of HER2-gene polymorphisms -1985G>T and P1170A C>G and their association with the risk of development of lung adenocarcinoma

Autori
Aleric, Ivan ; Katalinic, Darko ; Vcev, Aleksandar ; Kattner, Elke ; Bildat, Stephan, Krieger-Borgstaedt, Veronica ; Toetome, Lars

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Annals of Oncology / X, x - Barcelona : Oxford University Press, 2019, X-x

Skup
44th Congress of the European Society for Medical Oncology (ESMO)

Mjesto i datum
Barcelona, Španjolska, 27.09.2019. - 01.10.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HER2-gene polymorphism, 1985G>T, P1170A C>G, lung adenocarcinoma

Sažetak
Background: HER2-gene mutations are considered to be an important prognostic factor in patients with lung cancer. The aim of our study was to assess the frequency and signicance of HER2-gene single nucleotide polymorphisms -1985G>T and P1170AC>G among the patients with small-cell and non-small cell lung cancer and to compare this data to healthy subjects. Methods: The study was performed among 359 patients (69% males and 31% females ; mean age of 59.96 ± 18.24 years) with diagnosis of stage IV small-cell (24.6% of patients) and nonsmall cell lung cancer (75.4% of patients) compared to 167 healthy subjects (72% males and 28% females ; mean age of 69.96 ± 11.74 years). The frequencies of two polymorphisms of the HER-2-gene -1985G>T and P1170A C>G were detected using the quantitative real-time polymerase chain reaction (qRT-PCR) restriction fragment length polymorphism (RFLP) assay. The study was conducted according to the Declaration ofHelsinki, the protocol was reviewed and approved by the institutional Ethics committee and all patients provided written informed consent. Results: We found statistically signicant dierence in the distribution of genetic mutation variants -1985G>T and P1170A C>G among the patients with lung adenocarcinoma compared to healthy subjects (p < 0.001). The -1985G>T and P1170A C>G allelic variants were not signicantly expressed among the patient and control groups in overall subject (p = 0.874). Conclusions: Our study indicates that the expressions of genetic variants -1985G>T and P1170A C>G is associated with higher risk of development of lung adenocarcinoma. There was no statistical dierence among patient and control groups in overall subjects.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Dentalna medicina

POVEZANOST RADA