Naslov
Ferrocene peptidomimetics

Autori
Barišić, Lidija ; Kovačević, Monika ; Radošević, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Peptide Chemistry Day / Ruža Frkanec, Danijel Namjesnik - Zagreb : Sveučilište u Zagrebu, 2019, 5-5

ISBN
978-953-8250-03-3

Skup
Peptide Chemistry Day

Mjesto i datum
Zagreb, Hrvatska, 19.09.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Recenziran

Ključne riječi
ferrocene, peptidomimetics, conformational analysis

Sažetak
The peptidomimetics are peptide or non-peptide molecules with a potential for enhanced conformational stability and activity compared with natural peptides. One of the numerous design approaches utilizes a small molecular scaffold aimed to induce the formation of turn structures upon insertion into the peptide backbone. Owing to the distance between cyclopentadiene rings, 1, 1′-disubstituted ferrocene scaffolds exhibit a great potential to nucleate turns and -sheet-like structures in the derived peptides. The recent results obtained on conjugates of Ala‒Pro sequences and ‒NH‒Fn‒NH‒ scaffold (Fn = ferrocenylene) revealed a different conformational properties of homo- and heterochiral peptides. Also, the bulkiness and basicity of the N-terminal Boc and Ac groups were founded to influence their conformational behaviour.[1] Novel ferrocene peptides 1-4 are synthesized to explore not only the impact of the backbone chirality and N-terminal groups, but also the influence of a ferrocene scaffold ‒NH‒Fn‒CO‒ on their conformational patterning. Furthermore, the ability of the prepared conjugates to inhibit the growth of estrogen receptor-responsive MCF-7 mammary carcinoma cells and HeLa cervical carcinoma cells is tested.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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