Naslov
Enhanced protection of biological membranes during lipid peroxidation using flavonoid loaded mesoporous silica nanoparticles

Autori
Sadžak, Anja ; Mandić, Lucija ; Strasser, Vida ; Baranović, Goran ; Domazet Jurašin, Darija ; Dutour Sikirić, Maja ; Šegota, Suzana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
33rd Conference of The European Colloid and Interface Society : Book of abstracts / Koos, Erin ; Demeyere, Hugo - Leuven : The European Colloid and Interface Society, 2019, 43-43

Skup
33rd Conference of The European Colloid and Interface Society

Mjesto i datum
Leuven, Belgija, 08.09.2019. - 13.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Lipid peroxidation ; flavonoids ; silica nanoparticles

Sažetak
Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is rendered by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes (unsaturated DOPC) using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin and myricitrin have been investigated in order to determine the relationship between flavonoid structure and protective activity towards oxidative stress i.e. lipid peroxidation induced by addition of hydrogen peroxide and/or Cu2+ ions. Among investigated flavonoids, quercetin showed the most enhanced and prolonged protective anti- oxidative activity. The nanomechanical (Young modulus) measurement of the MSNs treated DOPC membranes during lipid peroxidation confirmed attenuated membrane damage. By applying combination of experimental techniques (AFM, force spectroscopy, ELS, DLS), this work generated detailed knowledge about the effects of flavonoid loaded MSNs on the elasticity of model membranes, especially under oxidative stress conditions. Results from this study will pave the way towards the development of innovative and improved markers for oxidative stress-associated neurological disorders. In addition, the obtained could be extended to designing effective delivery systems of other high potential bioactive molecules with an aim to improve human health in general.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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