Naslov
Application of adamantyl aminoguanidines infunctional self-assembled nanovesicles

Autori
Šekutor, Marina ; Štimac, Adela ; Tokić, Matea ; Ljubetić, Ajasja ; Vuletić, Tomislav ; Požar, Josip ; Leko, Katarina ; Hanževački, Marko ; Frkanec, Leo ; Frkanec, Ruža

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ESOR 2019 - 17th European Symposium on Organic Reactivity : Book of abstracts / Vančik, Hrvoj ; Namjesnik, Danijel - Zagreb : Hrvatsko kemijsko društvo, 2019, OP-14

ISBN
978-953-55232-9-1

Skup
17th European Symposium on Organic Reactivity (ESOR 2019)

Mjesto i datum
Dubrovnik, Hrvatska, 08.09.2019. - 13.09.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
adamantyl aminoguanidines ; model membrane systems ; nanovesicles ; liposomes

Sažetak
Combination of a lipophilic adamantyl subunit and a highly polar guanidine moiety affords adamantylaminoguanidines, compounds with membrane compatible features capable of binding to complementary molecules possessing phosphate groups.[1] We recently showed that adamantylaminoguanidines can effectively be incorporated into liposomes and the resulting liposomeformulations were capable of recognizing complementary liposomes.[2] We therefore turned outattention to preparing multicomponent self-assembled supramolecular nanovesicles capable of recognition and binding to fluorescently labelled DNA.[3] Our findings suggest that such nanovesicles(Figure 1) could potentially be applied as nonviral gene delivery vectors.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA