Naslov
Sex-related in vivo response to silver nanoparticles after subacute oral exposure

Autori
Barbir, Rinea ; Goessler, Walter ; Ćurlin, Marija ; Dabelić, Sanja ; Micek, Vedran ; Pavičić, Ivan ; Vinković Vrček, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
12th International Particle Toxicology conference / - Salzburg, 2019, 112-112

Skup
12th International Particle Toxicology Conference (IPTC 2019)

Mjesto i datum
Salzburg, Austrija, 11.09.2019. - 13.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
silver nanoparticles, oxidative stress response, biodistribution, sex differences

Sažetak
Exploitation of silver nanoparticles (AgNPs) in biomedicine represents more than one third of their overall application. Despite their wide use, detailed toxicokinetic data and mechanisms of AgNPs actions in vivo are still scarce. [1, 2]. There is still need for to gather more data to properly determine health implications, occupational and medical risks and hazards related to the use of AgNPs. In particular, sex-related response and averse outcome pathways are under-recognised and not well integrated into the design and applications of nano-enabled medical products [3]. Motivated by raising awareness of difference in biological response between sexes, this study evaluated bio distribution and oxidative stress response were studied in male and female Wistar rats following chronic oral exposure to AgNPs. Following 28 days oral administration of AgNPs, blood and organs were harvested from sacrificed animals. All procedure were in full compliance with animal welfare international standards and national legislation. Biodistribution of AgNPs were determined by measuring total Ag levels in different organs using inductively coupled plasma mass spectrometer (ICP-MS). Biomarkers for oxidative stress were determined in blood, liver and kidneys employing commercial assays. The observed differences in the response of males vs. females were significant for all parameters emphasizing the demand for evaluations of sex-related response to nanomaterials in further research and evaluations.

Izvorni jezik
Engleski

POVEZANOST RADA