Naslov
Ferrocene-containing asymmetric curcuminoid pyrazoles – a new potentially biologically active compounds

Autori
Kovač, Veronika ; Lukačević Tea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
26th Croatian Meeting of Chemists and Chemical Engineers with international participation

Mjesto i datum
Šibenik, Hrvatska, 09.04.2019. - 12.04.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
Ferrocene, Curcuminoid analogues, Curcuminoid pyrazoles

Sažetak
Curcuminoids are the most active ingredients of turmeric rhizome (Curcuma species -Zingiberaceae) that originates from India, Southeast Asia and Indonesia, amongst which curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) is the most studied and showed a wild range of interesting biological activities, such as anti-inflammatory, antioxidant, antimicrobial, neuroprotective, antimutagenic, anticarcinogenic and chemopreventive activities 1, 2. In spite of its broad spectrum of activities and non-toxicity even at high dosages, curcumin has poor oral bioavailability due to its low water and plasma solubility as well as its instability under physiological conditions which limits its clinical application 3, 4. Whereas presence of the methylene group and β-diketone moiety contributes to rapid degradation of curcumin, different curcumin analogues without β-diketone moiety have been synthesized and they mostly showed retained or increased various biological activities 2. Notable among these synthetic compounds are symmetric and asymmetric curcuminoid pyrazoles, in which 1, 3-diketone-enol system has been masked and rigidized with heterocyclic pyrazole ring. Due to their interesting pharmacological properties they are subject of many research papers 5. Herein is presented a synthesis of new asymmetric curcuminoid pyrazoles containing the ferrocene moiety (Figure 1) whose biological evaluation, such as antioxidant, antimicrobial and cytotoxic activities, will be studied.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA